Objective: To evaluate predictive factors between serum inflammatory markers and malignancy potential of endometrium. Methods: This retrospective study was conducted at the gynecological oncology unit, department of obstetrics and gynecology, at the faculty of medicine of Thammasat University. The study period was from 2017 to 2020. Endometrial cancer and benign gynecologic disease cases who underwent hysterectomy (with or without adnexectomy) during the study period were recruited. Demographic characteristics, histopathology reports and serum markers were also collected. Results: The study included a study group of 49 participants with endometrial cancer and a control group consisting of 119 cases of benign uterine disease. The study group had statistically significantly higher mean ages, proportional menopausal status and instances of underlying diseases when compared with the control group. Neutrophil/Lymphocyte ratios (NLR) and Platelet/Lymphocyte ratios (PLR) could not meaningfully predict the malignant potential of endometrium in hysterectomy specimens. NLR and PLR were statistically associated with depth of myometrial invasion (MI) in endometrial cancer cases. NLR equal to or greater than 1.93 predicted MI more than half thickness with sensitivity, specificity, accuracy, positive (PPV) and negative predictive value (NPV) at a percentage of 83.3, 52.8, 37.0, 90.5 and 60.4, respectively. PLR equal to or greater than 134.95 predicted MI of greater than fifty percent thickness with sensitivity, specificity, accuracy, PPV and NPV at 75.0, 55.6, 36.0, 87.0 and 60.4 percent, respectively. Conclusion: NLR and PLR have positive associations with myometrial invasion of endometrial cancer.

Providing the most recent information by World Health Organization, cervical cancer is by far the fourth most prevalent cancer in women with an incidence of 13.3% or around 604,000 new cases and 342 000 deaths in 2020. Reports also revealed that low-to middle-income countries represent 90% of the new cases and deaths worldwide in 2020 (Sung et al., 2021;Sung et al., 2021).Correspondingly, National Cancer Institute of Thailand (NCI) revealed that cervical cancer remains the prominent type of neoplasm in Thai female that responsible for 11.1% of new cancer cases in Thai women (Ministry of Public Health Thailand., 2020).With elaborated recognition, it had been proven for over 50 years that cervical cancer is sexually transmitted cancer caused by human papillomavirus (HPV) (Anderson et al., 2020). Papanicolaou smear (Pap smear) and visual inspection with acetic acid (VIA) are offered free of charge in Thailand (Insamran et al., 2020).Despite justified efficacy and accessibility of the test,