Replicated blood typing reagents were made to detect an interaction antigen (hybrid substance) on the red cells of several species hybrids of birds. Reagents against pigeon X ringneck dove hybrids are compared with other reagents made in an effort to find a similar interaction in the chicken X guinea fowl hybrid and in the ringneck X mourning dove hybrid. Mallard X muscovy hybrids also were tested for their reported red cell interaction product. Both rabbits and parental types were injected with the hybrids' red cells from the chicken X guinea fowl and mallard X muscovy crosses, but no interaction product was disclosed. The single reagent against the ringneck X mourning dove hybrid also failed to detect an interaction product.