It has been increasingly recognized that the application of simulation methods can be instrumental in addressing the multi-faceted challenges health care is facing at present and more importantly in the future. But the application of these methods seems not to be as widespread as in other sectors, where such methods when used as part of their core operation, reap significant benefits. This paper examines the potential use of modeling and simulation in health care, drawing the parallels and marking the mismatches from the business and manufacturing world. Methods from the latter sectors will be reviewed with the intention to assess their potential usefulness to healthcare. To focus this discussion, we propose and discuss seven axes of differentiation: patient fear of death; medical practitioners (for example approach to healing, investigation by experimentation and finance); healthcare support staff; health care managers; political influence and control; 'society's view'; and utopia
The impact of elective infrarenal aortic clamping on parameters of renal function was evaluated in 27 extracellular fluid volume expanded patients. Significant transient decreases (p < 0.05) in glomerular filtration rate were observed in all three groups either in the early or late post-clamp release period, despite maintenance of hemo-dynamic stability. This study documents transient decreases in glomerular filtration rate which occurred following release of the infrarenal aortic cross-clamp. No clinically important benefit from the use of mannitol and dopamine over extracellular fluid volume expansion with saline alone was demonstrated in the prevention of the changes in renal function associated with aortic cross-clamping.
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