Objectives: The aim of this systematic review and meta-analysis is to assess the degree of stability of anterior open bite (AOB) treatment performed through the molar intrusion supported with skeletal anchorage at least 1 year posttreatment. Methods: This study was registered in PROSPERO (CRD42016037513). A literature search was conducted to identify randomized (RCT) or non-randomized clinical trials based including those considering before and after design. Data sources were electronic databases including PubMed, Cochrane Library, Science Direct, Google Scholar, Scopus, Lilacs, OpenGrey, Web of Science, and ClinicalTrials.gov. The quality of evidence was assessed through the JBI tool and certainty of evidence was evaluated through the GRADE tool. Random effects meta-analysis was conducted when appropriate. Results: Six hundred twenty-four articles met the initial inclusion criteria. From these, only 6 remained. The mean posttreatment follow-up time was 2.5 years (SD = 1.04). The overbite showed a standardized mean relapse of − 1.23 mm (95% CI − 1.64, − 0.81, p < 0.0001). Maxillary and mandibular incisors presented a non-significant mean relapse, U1-PP − 0.04 mm (95% CI − 0.55, 0.48) and L1-MP − 0.10 mm (95% CI − 0.57, 0.37). Molar intrusion showed a relapse rate around 12% for the maxillary molars and a 27.2% for mandibular molars. Conclusion: The stability of AOB through molar intrusion using TADs can be considered relatively similar to that reported to surgical approaches, since 10 to 30% of relapse occurs both in maxillary and mandibular molars. The level of certainty ranged between very low and low. RCTs reporting dropout during the follow-up are in dire need.
Orofacial clefts are facial malformations caused by the improper development of the lips and palate. Many genetic and epigenetic molecules have been involved in the mechanisms of orofacial clefts, one of which are miRNAs. This systematic review aimed to identify miRNAs associated to non‐syndromic orofacial clefts in humans. After applying a series of criteria, four studies were selected for analysis. In total, one hundred miRNAs were observed in the literature, of which 57 were reported as upregulated and 43 as downregulated in all orofacial cleft classifications. Moreover, nine miRNAs were differentially expressed only in cleft palate patients, which might suggest distinct regulatory mechanisms for the etiology of cleft lips and palates. We suggest broader population sampling in order to include diverse ethnic groups in the future, as well as analyses toward identifying miRNA target genes and pathways. We highlight the need for experimental validation and of these results to allow further translational approaches and clinical applications.
A pandemia causada pelo novo coronavírus (COVID-19) já provocou a morte de mais 142 mil pessoas no Brasil, levando alguns Estados a decretarem colapso do sistema de saúde. A COVID-19 é uma doença de perfil sintomatológico variável, com espectro altamente diverso. No Brasil a grande maioria da população não tem acesso a testes diagnósticos para COVID-19 e estudar os sintomas clínicos se torna relevante para identificar possíveis disseminadores do vírus. Assim, o presente estudo teve como objetivo descrever os sintomas clínicos mais prevalentes em pacientes recuperados de COVID-19 em regiões da Amazônia oriental Brasileira. Para isso, foram aplicados questionários à pacientes testados positivo para Sars-Cov 2 afim de analisar os sintomas durante a infecção. Um total de 85 indivíduos participaram da pesquisa. Os sintomas observados em mais de 50% dos entrevistados foram febre, tosse, perda de olfato, rinite, dor de garganta, perda do paladar, dor na cabeça, dor nas articulações, dor na coluna, dor nas costas e dores musculares. Alguns dos pacientes após um curto período tornaram-se assintomáticos. Vale ressaltar que a compreensão exata dos sintomas clínicos da doença é de extrema importância, uma vez que a ampla variação observada faz com que o diagnóstico da COVID-19 seja complexo e desafiador.
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