When, in the 1980s, climate change entered into the UN agenda, the first question raised was: "What is the climate from a legal point of view?" After the Maltese proposal of 1988 to recognize “Climate as Common Heritage of Humankind”, the adopted UN resolution considered climate as “common concern of humanity”. The concern approach has transformed the positive approach of the Maltese initiative on “the heritage” into a negative approach of a damage containment and sharing system with an undefined obligation to cooperate. This fact makes it technically impossible to build an economy capable of producing positive impacts to recover a well-functioning of the Earth System, and consequently a stable climate. The fact is it fails to build an economic and governance system around the maintenance in a favorable condition of a common good that although intangible exists in natural world and is the very support of life. This paper briefly explores the legal origin of the climate negotiating deadlock resulting from the common concern approach, and the economic and social consequences of the legal non-existence of climate, i.e. a well-functioning Earth System, and points out to the concept of heritage as a way to overcome the obstacles that have prevented collective action.

Ovarian ageing stands as the major contributor towards fertility loss. As such, there is an urge for studies addressing the mechanisms that promote ovarian ageing and new strategies aiming to delay it. Recently, the presence of a unique population of multinucleated giant cells has been identified in the ovaries of reproductively aged mice. These cells have been considered hallmarks of ovarian ageing. However, up to date multinucleated giant cells have only been described in the ovaries of the mice. Therefore, the aim of the present work was to evaluate and characterize the presence of such hallmarks of ovarian ageing in the sheep and the goat. In this study, ovaries from juvenile (6 months) and mature animals (18–24 months) were used. The hematoxylin and eosin technique was performed to describe the ovarian morphology and evaluate the ovarian follicle reserve pool. Sudan black B staining and the detection of autofluorescence emission were used to identify and characterize the presence of multinucleated giant cells. Statistical analyses were performed with GraphPad Prism 9.0.0. A decrease in the follicle reserve pool and the presence of multinucleated giant cells, with lipofuscin accumulation and the emission of autofluorescence, were observed in the ovaries of the mature animals of both species. Our results support the interest in the use of the ovine and the caprine model, that share physiological and pathophysiological characteristics with humans, in future studies addressing ovarian ageing.

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O conteúdo do livro e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva da autora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos a autora, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.