In this study, no association is seen between the Pro12Ala polymorphism in PPAR gamma2 gene and diabetes; a weak association with obesity is seen.

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Background: Hypertension is happened generally at someone who has age more than 40 year. The prevalence of hypertension was tend to increase along with the increasing of amount of the elderly. Changing of nutrition status and unfavorable nutrition intakes like is high fat, sodium and low micronutrients (potassium, calcium, magnesium) have an effect to incidence of essential hypertension. Retreating of biologic accompanying aging process sometimes make the elderly become resistance to get quality of intakes nutrition.Objective: The study was conducted to know relations between nutrition intakes and nutrition status with occurrence on essential hypertension of the elderly in the health center Curup and Perumnas, Rejang Lebong District.Method: The study was observational analytic with case control matched study. Subject of the study was divided into two group i.e. case and control with comparison case and control 1:1 which matched to age and sex. Total subject were 150, taken by simple random method. The cases were essential hypertension patients who had recently diagnosed by doctors. Blood pressure measurements were three times in supine position. Hypertension was defined as average of three times supine systolic/diastolic blood pressures at p >140/ 90 mmHg. Nutrition status was determined by Body Mass Index (BMI). Intake nutrients were collected using Food Frequency Questionnaire (FFQ) in the last 3 months by using food model. χ 2 McNemar were used to bivariate analytic and condition logistic regression to identify risk factors associated with essential hypertension.Result: This study showed that there were 4 variables significantly related with essential hypertension, i.e. intakes of sodium (OR: 3.43; CI 95%:1.09-10.77), potassium (OR: 0.24; CI 95%:0.07-0.84), stress (OR: 3.79; CI 95%:1.18-12.12), and obesity (OR: 4.57; CI 95%:1.49-13.95). The no significant correlation (p>0.05) identified for intakes of fat, calcium, magnesium, coffee consumption, smoking status and family history of essential hypertension.Conclusion: High intake of sodium, stress and obesity were the risk factors on occurrence of essential hypertension. In the other hand, high intake of potassium were reduce the risk on occurrence of essential hypertension (protective factor) in the health center Curup and Perumnas, Rejang Lebong District.

AbstrakTelah dilakukan studi kasus kelola di Unit Rawat Jalan Bagian Neurologi RSIJP DR Sardjito Yogyalarta, indonesia. penelitian ini berrujuan untuk menentukan adanya hiperinsulinemia pada pendertta srrok tanpa disertai diabetes melitus. Penderita yang dimasul 045), namun dijumpai kadar insulin pasca-makan lebih tinggi bermakna (94,89 t 12,15 vs 55,21 + 6,88 ltU/mt, p . O,OSI pada kasus dibanding kzlola. Walaupun tidak dijumpai perbedaan bermakna dai kadar insulin puasa baik pada subkelompok TGN (toleransi glukose normal) dan TGT (toleransi glul

In an attempt to determine the presence of hypertension in stroke patients and its relationship with hyperinsulinaemia, a case-control study was carried out in the outpatients clinic, Department of Neurology, Sardjito General Hospital, Yogyakarta. Patients included in the study were those who had survived a stroke at least 3 months after the first attack. The exclusion criteria included: diabetes mellitus, renal failure, heart failure, malignancy, myocardial infarction, current antihypertensive and hypolidaemic treatment. Controls were selected from non-stroke patients at the same department matching for sex and age. During the study 51 stroke patients (39 male and 12 female, aged 58.7 f 10.3 years) and 51 controls (40 male and 11 female, aged 58.6f9.8 years). There were no significant differences in baseline clinical characteristics; namely, smoking, body mass index, blood sugar and blood lipids except triglyceride ( 169 f 61 vs 141 f 6 0 R0.05) of cases and controls. Although there was no significant difference of fasting plasma insulin levels (9.3 f 8.3 vs 8.3 f 2.6 mU/L, P = >0.05), significantly higher levels of postprandial insulin (94.8f86.7 vs 55.2 f49.1 mU/L, R0.05) were found in cases than controls. There were a significantly higher levels of blood pressure, both systolic (16Of24 vs 131 f 11 mmHg, R0.05) and diastolic (101 f 13 vs 7 9 5 4 mmHg, P<0.05), and more frequent hypertension defined as B P 2 140/90 mmHg (72.5 vs 2.0%, P<0.05) in cases than controls. No significant difference of plasma insulin levels (94.9 k 82.3 vs 94.3 f 119.2 mU/L, b0.05) between hypertensive and normotensive stroke patients. However, significantly higher levels of insulin (94.3 f 119.2 mU/L vs 55.2 k49.1 mU/L, P<0.05) were found in normotensive stroke patients than controls. The relationship between 2 h post-prandial blood sugar levels and post-prandial insulin levels was positive and nearly significant relationship (r = 0.62, P = 0.05). The relationship between mean arterial pressure (MAP) and post-prandial insulin levels of the whole patients (cases and controls) were poor but significant (r =0.22, R0.05). The relationship between MAP and post-prandial insulin levels are poor and not significant both in stroke patients (r=O.OO, P>0.05) and controls (r=0.17, b0.05). The slope of both curves in both scattered diagrams seemed to be slightly different. We conclude that hypertension and post prandial hyperinsulinaemia may play a role in the genesis of stroke, while hyperinsulinaemia may an independent factor.