Persistent infection of Human papillomavirus (HPV) is the strongest epidemiological factor associated with intraepithelial neoplasia and cervical cancer. These days, infection with Human papillomavirus is the most common type of sexually transmitted disease. In most cases, infection is asymptomatic and it remains undiagnosed.Women infected with high-risk types of the virus are at greater risk of developing severe dysplastic changes or cancer. The aim of this study was to examine the association between HPV type 16/18, cytology, colposcopy, biopsy and risk factors of developing intraepithelial lesions of low L-sIL and a high level of H-sIL. The study included 864 patients who had undergone detection of HPV type 16/18 dNa using in situ hybridization. all study participants were divided into three categories according to the presence of H-sIL, L-sIL and benign histologic findings. In the case study group that had L-sIL and H-sIL there was a significant higher percentage of HPV infection than in the group of patients with benign histologic findings. The percentage of H-sIL is highest in patients who had Hr-HPV infection with types 16/18, sexual intercourse before 16 the age and two to five sexual partners.This study indicates that among the H-sIL intraepithelial neoplasia, there is a high presence of Hr-HPV 16/18 related to the number of sexual partners and early sexual intercourse at a younger age as a statistically significant presence of these genotypes with L-sIL intraepithelial neoplasia.Key words: HPV infection types 16/18, premalignant changes in the cervix.HPV tipovi 16/18 u korelacija sa kolposkopijom, citologijom, histopatologijom i najčešćim faktorima rizika u nastanku L-siL i H-siL intraepitelnih lezija Paunović Vesna 1 , Paunović Tomislav 2 , Konević slavica 3 , Vasiljević slađana 4 1,2 Medicinski fakultet, Ginekološko akušerska klinika "Narodni front" -Beograd, srbija 3 dom zdravlja rakovica -Beograd, srbija 4 dom zdravlja Zemun -Beograd, srbija apstrakt Perzistentna infekcija Humanim papiloma virusima je najsnažniji epidemiološki factor povezan sa intraepitelnim neoplazijama i rakom grlića materice. Infekcija humanim papiloma virusom danas je najčešći tip seksualno prenosive bolesti.Kod žena inficiranih visokorizičnim tipovima virusa postoji veći rizik od razvoja težih displastičnih promena, odnosno karcinoma. Cilj ove studije bio je da ispita povezanost između infekcije HPV tip 16/18, citologije, kolposkopije, biopsije i faktora rizika u nastanku intraepitelnih lezija niskog L-sIL i visokog stepena H-sIL . U studiju bilo je uključeno 864 pacijentkinje kod kojih je urađena HPV tipizacija na genotipove 16/18 metodom dNK in situ hibridizacije. svi učesnici studije su podeljeni u tri kategorije prema prisustvu H-sIL, L-sIL i histološki benignog nalaza. U studijskoj grupi slučajeva koje su imale L-sIL i H-sIL dokazan je značajno veći procenat HPV infekcija u odnosu na grupu pacijentkinja sa benignim histološkim nalazom. Procenat H-sIL je najveći kod pacijentkinja koje su imale infekciju Hr-HPV tip...