The problem of the medical application of non-invasive (The specially devised multifunctional laser diagnostic system “LAKK-M” was used as a diagnostic instrument in the majority of studies in MONIKI, allowing a combination of methods, such as non-invasive medical spectrophotometry in the form of laser fluorescence spectroscopy, laser Doppler flowmetry, tissue reflectance oximetry, etc. The system was used in both the experiments on laboratory animals, and for treatment of patients in different clinics of the institute.Within the last decade, extensive scientific data has been obtained which has opened up the possibility of using non-invasive medical spectrophotometryMethods of complex non-invasive medical spectrophotometry appear to be an efficient tool in practical medicine for differential diagnostics of a number of diseases and pathologies, as well as for monitoring and prediction of the treatment outcome. At the same time, they also create an important perspective for gaining novel and fundamental knowledge about the blood microcirculation system which was not available earlier due to the absence of the diagnostic technology allowing information to be obtained

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The laser "in vivo" autofluorescence diagnostics is now widely studied and applied in different areas of medicine, such as an oncology, dermatology, etc. Recently we have reported of created new professional multiwave laser diagnostic system (MLDS) for this purpose under the international scientific research and development project #1001 supported by the International Scientific and Technology Center. This presentation lights some results of application of the MLDS in a real clinical practice at Moscow Regional Research and Clinical Institute "MONIKI", Department of Radiology. With the use of MLDS we investigated a skin and oral cavity cancer endogenous fluorescence before, during and after standard radiotherapy treatment. A statistical analysis showed that the best radiotherapy result was achieved for the patients with a small initial porfirines' autofluorescence and a great initial flavines' one from irradiated tumor tissues. It was shown that each radiotherapy procedure has an influen ce on a tissues' autofluorescence intensity. The tendencies in porfirines' fluorescence during a treatment course can be an additional prognostic factor for the prediction of the efficacy of a radiotherapy treatment. Moreover, it was estimated that a number of non-cancerous skin disease has a typical "cancer" initial autofluorescence, that makes it difficult to distinguish them one from another with the use of only the fluorescence diagnostics, but opens the way to investigate the non-cancerous tissues diseases with the help of tissues endogenous fluorescence phenomenon.

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