The study included 218 patients with heart failure (HF) on the background of post-infarction cardiosclerosis who had non-toxic goiter (NG). 109 (50.0 %) patients received levothyroxine (LT) in connection with NG. Whether the levels of TSH, T3f, T4f, T3r were determined. Echocardioscopy and ultrasound examination of the thyroid gland were conducted. We studied the course of heart failure for 2 years. Patients who used LT, comparing with patients without this drug, had smaller dimensions (EDD and ESD) and volumes (ESV and EDV) of left ventricle (LV) and 22.9 % greater LV ejection fraction (EF) (p = 0.0001), as well as higher low serum NT-proBNP level (26.3 %, p = 0.009). In the subgroup of patients taking LT at a dose of 0.1 to 0.69 μg/kg, LVEF did not differ from patients without this tritment. At a dose of 0.7-1.19 μg/kg, LVEF is higher compared with that of patients who did not take LT (by 37.9%) and patients who took LT at a dose 0.1−0.33 mcg/kg (36.9 %). LVEF was the highest in patients taking LT at a dose of > 1.20 mcg/kg. The use of LT for 2 years reduces the risk of re-hospitalization (RH) due to decompensation of heart failure (Odds ratio = 0.490 (0.281−0.857), p = 0.018) and a tendentious decrease in the risk of combined endpiont achieving (by 27.9 %, p = 0.074). The ROC analysis showed that the risk of RH in patients with heart failure due to decompensation of the disease decreases with the use of LT at a dose of > 0.53 μg/kg (sensitivity − 56.62 %, specificity − 60.98 %, p = 0.016). The use of LT in patients has a dose-dependent positive effect on LVEF. The largest LVEF is observed in patients taking the drug at a dose of> 1.2 mcg/kg. The use of an LT dose of > 0.53 mcg/kg leads to a significant decrease in the frequency of re-hospitalization due to decompensation of heart failure during 2 years.

Purpose: According to many scholars, sport is essential for social adaptation and integration of people with disabilities. Therefore, it is important to research innovative technologies for teaching competitive swimming technique to 8-10-year- old children with cerebral palsy. The aim of this study is to develop the technology of teaching competitive swimming techniques to children with cerebral palsy and to evaluate its effectiveness for mastering the front crawl swimming technique. Materials and methods: analysis of scientific literature, questionnaires (e-correspondence), pedagogical experiment, expert survey, determination of the coefficient of technique efficiency, statistical methods. A total of 15 qualified swimming coaches participated in this study. The experiment involved 29 children who were diagnosed with cerebral palsy. Results: the main means of technology implementation is the web-based information system SwimCP (Swimming with Cerebral Palsy), which promotes effective swimming teaching for children with cerebral palsy at the initial stage of sports training by selecting and recommending an approximate complex of exercises that take into account the peculiarities of motor disturbance in accordance with the specific form of cerebral palsy and the stage of motor activity training. Conclusion: using expert assessment and the coefficient of swimming technique efficiency determination, it is confirmed that the proposed technology of teaching basic competitive swimming techniques to children with cerebral palsy is effective. Resumen: Objetivo: Según muchos estudiosos destacados, el deporte es fundamental para la adaptación social y la integración de las personas con discapacidad. Por lo tanto, es importante investigar modelos innovadores para enseñar brazadas de natación competitiva a niños con parálisis cerebral. El objetivo del estudio es diseñar el modelo pedagógico de enseñanza de los estilos básicos de natación competitiva a niños con parálisis cerebral y evaluar su efectividad para dominar el estilo de natación estilo crol. Material y métodos: Se utilizó una metodología de investigación selectiva. Implicó la recopilación directa de datos gracias a la encuesta a los participantes. Los resultados mostraron que el nivel de dominio de la brazada de natación utilizado por los niños que aplicaron este modelo diseñado fue objetivamente mayor en comparación con los mismos indicadores de entrenamiento relacionados con el método tradicional. Conclusiones: Basándonos en la evaluación de la eficiencia de la brazada de natación, creemos que el modelo pedagógico propuesto de enseñar las brazadas básicas de natación competitiva a niños con parálisis cerebral es eficaz.

No abstract

The various processes occurring in the body are controlled, i.e. their condition is determined depending on the specific influence of the controlling party. At the same time, it is natural to try to choose the optimal control effect, the best in comparison with other possible control methods. It is clear that for a living organism to optimize the choice of control effect it is necessary to simulate on a mathematical model that would allow real-time simulation of perturbations and predict the functional state of the organism due to these perturbations. This applies, in particular, to predicting the response of functional systems of the body in viral disease. The paper generalizes a mathematical model of the functional respiratory system that would take into account the different nature of air movement in the airways (laminar, turbulent, mixed). The components of the model are models of transport of respiratory gases in the airways, alveolar space, pulmonary capillary blood, arterial blood, tissue capillary blood, tissues and mixed venous blood and self-organization of the respiratory and circulatory system. The proposed computational procedure can be applied taking into account the array of individual data for the selection of modes of artificial lung ventilation in the case of severe COVID 19.

Introduction.Various processes going in surrounding environment are controlled, i. e. their states are determined depending on the specific influence of controlling party. At the same time, it is natural to try to choose the optimal controlling influence that would be the best in comparison with other possible controlling methods. Intensive development of the theory of optimal solutions with computers use has obtained the ability to perform complex calculations and realize the rules of control due to the development of computational technology.