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In this paper, we propose a cross-layer MAC/PHY (Medium Access Control Layer/Physical layer) framework to increase the throughput respecting a target packet error rate (PER) required by the nodes. High capacity CDMA ad hoc network with full multiuser detection (MUD) MAC layer is considered. The fundamental scenario studied is made of a terminal or radio which detects several neighbors' signals by the means of a multi-user detector. At the receiver's level, adaptive filter, rate adaptation scheme, and multi-rate transmitter are integrated in a predictive framework that connects MAC and physical layer mechanisms. Then the performances are evaluated by simulation where PER guarantee transmissions are compared to simple existing systems. The results show the performance gain of the PER guarantee transmissions.