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A 27.5-to 43.5-GHz up-conversion mixer is presented for fifth-generation (5G) applications in 65-nm CMOS process. A two-path transconductance stage (TPTS) is demonstrated to improve the linearity. Compared with the conventional common-source stage, this method enhances the output 1-dB compression point (OP 1dB ) by 3.45 dB only at a cost of 1-mW extra power. Moreover, the input and output baluns are using the fourth-order transformer-based resonators to realize a wideband impendence matching. With a power consumption of 14 mW, the proposed up-conversion mixer achieves OP 1dB of 0.42 dBm at 38 GHz. Simultaneously, the maximum conversion gain of −5 dB, local oscillator (LO)-to-intermediate frequency (IF) isolation of 43 dB and LO-to-radio frequency (RF) isolation of 40 dB are obtained.This paper presents a wideband high linearity up-conversion mixer for 5G applications in 65-nm CMOS process. A TPTS technique and fourth-order transformer-based resonators are analyzed and employed to improve the linearity and bandwidth of this mixer. Measurement results show the mixer achieves an OP 1dB of 0.42 dBm at 38 GHz, while consuming only 14 mW from a 1-V supply. Furthermore, it also demonstrates a large bandwidth from 27.5 to 43.5 GHz, which is suitable for the 5G applications including 28 and 38 GHz frequency bands. 8 of 9 CHEN ET AL. 8 of 9 CHEN ET AL. How to cite this article: Chen Z, Liu Z, Jiang Z, et al. A 27.5-43.5 GHz 65-nm CMOS up-conversion mixer with 0.42 dBm OP 1dB for 5G applications. Int J Numer Model. 2019;e2550. https://doi.org/10.1002/jnm.2550 CHEN ET AL. 9 of 9 0.42 dBm OP 1dB for 5G applications. Int J Numer Model. 2020;33:e2550. https://doi.