A facile and eminent method has been reported for the preparation of amido alkyl naphthols. Amido alkyl naphthol derivatives were synthesized by the condensation of pyrazole aldehydes, β-naphthol and acetamide in the presence of a heterogeneous SiO2 supported sodium hydrogen sulphate catalyst using acetic acid as a solvent. This protocol is advantageous for its shorter reaction hours, simplest workup technique, excellent yields with easy recovery and reusability of the catalyst.1H, and 13C Nuclear Magnetic Resonance, Fourier transform infrared and Mass Spectroscopy were utilized for the characterization of synthesized products.

A catalyst-free synthetic strategy to chromene carbonitriles by Multi-Component Reaction of pyrazole aldehydes, 5,5-dimethylcyclohexane-1,3-dione and malononitrile with ethanol, at room temperature is reported. Screening of solvents and purification of the compounds were also performed. The newly synthesized novel compound’s (4H-chromene-3-carbonitriles) structures were authenticated by the spectral techniques viz. (1H , 13C)Nuclear Magnetic Resonance, FT-IR, and LC-MS analysis.

A new, efficient and catalyst-free synthetic strategy was developed for ten carbonitriles by the combination of pyrazole aldehydes and hydroxylamine hydrochloride in the presence of green solvent-glycerol. All the synthesized carbonitriles were confirmed from by 1H, 13C NMR and high resolution mass spectroscopies. The proposed synthetic process was simple, effective with high product yields and environmentally benign with mild reaction conditions.

A straightforward synthetic procedure for thioamides has been developed at 100 ºC using pyrazole aldehyde, a secondary amine, precipitated elemental sulphur and DMSO as solvent. The Willgerodt-Kindler reaction was successfully carried out by increasing the mole ratio of the precipitated sulphur and amine derivatives. The synthesized thioamides derivatives were characterized by 1H and 13C NMR, FT IR, HRMS spectrometric techniques. This method has various advantages, including high yields, a relatively rapid reaction time and the ability to operate in catalyst-free conditions.