SUMMARY Gastric emptying of isotopically labelled solid meals was studied in normal human subjects and in patients at different intervals after truncal vagotomy and Heineke-Mikulicz pyloroplasty.One to four weeks after vagotomy and pyloroplasty gastric emptying was delayed grossly in some patients regardless of the completeness of vagotomy. Patients with gross delay had symptoms of gastric retention. Eight weeks later emptying had returned towards normal and one or more years after vagotomy and pyloroplasty emptying was within the normal range.A subthreshold dose of carbachol injected during the course of emptying of a meal in some of the postvagotomy patients had no detectable influence on the rate of emptying of the meal.

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ABSTRACT. The geographical distribution of the drumlins was studied. They are arranged in bands perpendicular to ice pressure with a weaker alignment parallel to ice flow. An hypothesis of drumlin origin is presented. Two ice flows are present, a strong flow from an Irish centre to the north-west, and a weaker flow of Scottish ice from the north. REsuME. Drumlins et ecoulement pliistocene de la glace sur la Ards Peninsula, region de Strangford Lough, CountyDown, Ireland. On a etudie la distribution des drumlins. lis sont ranges en ban des perpendiculaires a la pression de la glace avec un alignement moins marque parallele a l'ecoulement de la glace. On peut distinguer deux courants de glace, le plus fort d'un centre irlandais vers le nord-ouest, et un courant plus faible de glace ecossaise venant du nord. ZUSAMMENFASSUNG. Drumlins und Fliessrichtung des Eises im Pleistoziin uher dem Ards

We have used asthma as a model of airways disease to test how well an automated, quantitative method of analysis of lung scans correlates with physiological measurements of disturbed lung function and gas exchange. We studies 25 asthmatics (age 16-73) of widely differing severity (forced expiratory volume in 1-s (FEV1) 22%-123% of predicted value), who had airways tests, arterial blood gas analysis, and krypton-technetium lung scans within a short time of each other. In all patients with airways obstruction and in some with normal function during remission, scans showed the typical appearances of multiple defects of ventilation and perfusion. The severity of ventilation defects was computed from the posterior view of the krypton scan compared to an age- and sex-matched normal range to yield an underventilation score. This correlated closely with the severity of airways obstruction as measured by forced expiratory manoeuvres. Ventilation and perfusion defects were usually imperfectly matched; the severity of this was computed using a subtraction method applied to the counts on the posterior krypton and technetium scans. The degree of mismatch was inversely related to the arterial partial pressure of oxygen (r = -0.86). The results suggest that computer scan analysis can provide useful functional information about the lung in airways disease.

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