The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and-hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both contribute to the observed antiproliferative profile of these compounds against many cancer cell lines. This unprecedented dual anticancer mechanism may lead to a new approach for designing innovative therapeutic agents.

What is the most significant result of this study? Non-alkali metal azides are explosive compounds, which can hardly be considered as convenient and useful reagents in organic synthesis. However,a sw ed iscovered in our study the metal ion can modulate the reactivity of the azide anion thus opening new opportunities for the synthesis of organic azides. The compromise is that the use of af ree-metal azide is not needed, since it can be safely generated in solution by ion exchange from NaN 3 and the corresponding metal salt. What was the inspiration for this cover design? The inspiration for the cover picture came from cue sports. We make an analogy of the chemical behavior observed in our studies with ab illiard game, in which balls are ions, and pockets are reac-tive centers of an organic molecule. Unlike in ar eal game based on mechanics, in a" chemical billiard", ion balls after collision may not only bounce off each other,b ut also can fuse to form ac ova-lently bonded pair,w hich moves along its own trajectory.A "metal-ion ball" depending on its nature, directs the attack of the "azide-anion ball" on either one or another electrophilic "pocket" of the substrate (silicon or carbon atoms). Thus, ac hemist is like ap rofessional billiard player selecting the right ball (promoter/cat-alyst) and disposition (reaction conditions) to hit the target center in the molecule. This simple allegory illustrates the results described in our article in ap opular and easy-to-understand manner. What other topics are you working on at the moment? Although we are originally synthetic chemists, our research interests go far beyond the borders of traditional synthesis. Besides our focus on NÀOs ystems and stereoselective synthesis, we are working in the areas of medicinal chemistry,c lick reactions, coordination compounds, polymers and quantum-chemical calculations. Our particular passions are adamantane-like molecules. Among our recent achievements are the synthesis and structural studies of "isourotropine" (the isomer of methenamine) and B,O,N-doped adamantanes. Invited for the cover of this issue is the group of Alexey Sukhorukov at the N. D. ZelinskyI nstitute of Organic Chemistry. The image depicts the reaction pathways taken by metal azides as a" chemical billiard"g ame. Read the full text of the arti

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An approach to the synthesis of α‐halo oxime ethers from readily accessible nitronates and nitro compounds via bis(oxy)enamines is reported. A key step of the strategy involves the unprecedented reaction of bis(oxy)enamines with a metal (Co, Zn, Mg, Mn) halide that acts as both a promoter and halide (Br, I, Cl) source. A variety of cyclic and acyclic ethers of α‐halo oximes, including previously unavailable trimethylsilyl ethers of α‐iodo oximes, have been synthesized in good‐to‐high yields.

Exhaustive Michael-type alkylations of amines and ammonia with azoalkenes (generated from α-halohydrazones) were demonstrated as an efficient approach to poly(hydrazonomethyl)amines – a novel class of polynitrogen ligands. An intramolecular cyclotrimerization of C=N bonds in tris(hydrazonomethyl)amine to the respective 1,4,6,10-tetraazaadamantane derivative was demonstrated.