2017
DOI: 10.1002/chem.201605390
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Divergent Reactivity of In Situ Generated Metal Azides: Reaction with N,N‐Bis(oxy)enamines as a Case Study

Abstract: What is the most significant result of this study? Non-alkali metal azides are explosive compounds, which can hardly be considered as convenient and useful reagents in organic synthesis. However,a sw ed iscovered in our study the metal ion can modulate the reactivity of the azide anion thus opening new opportunities for the synthesis of organic azides. The compromise is that the use of af ree-metal azide is not needed, since it can be safely generated in solution by ion exchange from NaN 3 and the correspondin… Show more

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Cited by 24 publications
(20 citation statements)
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“…Here, we suggest in situ generated magnesium cyanide [NaCN/Mg(ClO 4 ) 2 ] as a non‐volatile, soluble in DMF and cheap reagent for 1,2‐ and 1,4‐hydrocyanation reactions . It combines a nucleophilic cyanide anion and a Lewis acid (Mg 2+ ), which covalently binds to anions A preventing their degradation and can be easily removed by aqueous work‐up.…”
Section: Introductionmentioning
confidence: 99%
“…Here, we suggest in situ generated magnesium cyanide [NaCN/Mg(ClO 4 ) 2 ] as a non‐volatile, soluble in DMF and cheap reagent for 1,2‐ and 1,4‐hydrocyanation reactions . It combines a nucleophilic cyanide anion and a Lewis acid (Mg 2+ ), which covalently binds to anions A preventing their degradation and can be easily removed by aqueous work‐up.…”
Section: Introductionmentioning
confidence: 99%
“…In our studies, N , N ‐bis(oxy)enamines (BENAs), which are readily accessible by the silylation of nitronates or nitroalkanes, were used as model substrates (Scheme ) . BENAs possess multiple reaction sites, which can undergo reactions with protic acids.…”
Section: Resultsmentioning
confidence: 99%
“…Calcium carbide was purchased from Shanghai Macklin Biochemical Co. Ltd (purity: 98 %), and ground into powder prior to use. Various azide ketoximes 1a – 1t were synthesized by the reactions of the corresponding bromoketoximes with sodium azide according to literature procedures ( 1a–1h , 1j , 1k and 1m – 1t ; 1i ; 1l ). Other reagents were purchased from Energy Chemical Company (China).…”
Section: Methodsmentioning
confidence: 99%