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The global development of technologies now enters areas related to human health, with a transition from conventional to personalized medicine that is based to a significant extent on (bio)printing. The goal of this article is to review some of the published scientific literature and to highlight the importance and potential benefits of using 3D (bio)printing techniques in contemporary personalized medicine and also to offer future perspectives in this research field. The article is prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect databases were used in the literature search. Six authors independently performed the search, study selection, and data extraction. This review focuses on 3D bio(printing) in personalized medicine and provides a classification of 3D bio(printing) benefits in several categories: overcoming the shortage of organs for transplantation, elimination of problems due to the difference between sexes in organ transplantation, reducing the cases of rejection of transplanted organs, enhancing the survival of patients with transplantation, drug research and development, elimination of genetic/congenital defects in tissues and organs, and surgery planning and medical training for young doctors. In particular, we highlight the benefits of each 3D bio(printing) applications included along with the associated scientific reports from recent literature. In addition, we present an overview of some of the challenges that need to be overcome in the applications of 3D bioprinting in personalized medicine. The reviewed articles lead to the conclusion that bioprinting may be adopted as a revolution in the development of personalized, medicine and it has a huge potential in the near future to become a gold standard in future healthcare in the world.

Objective: Corridor tests (CT) are validated tools used to measure the effects of rehabilitation interventions in frail elderly subjects. Recently the six-minute walk test (6MWT) was introduced in the assessment of frail individuals. The purpose of this study was to investigate the use of the 6MWT as a tool for measurement the functional capacity and mobility in different frail populations with chronic heart failure (CHF). Methods: In this study 6MWT was applied in seventy-five (n=75) individuals randomized into two training groups for a 12 th week period; group A (n=38) performed high-intensity aerobic interval training (HIAIT), while group B (n=37) fulfilled moderate intensive continuous training (MICT), for measuring the impact in the effectiveness in two different intensity cardiac rehabilitation (CR) interventions in patients with CHF. Results: The data indicate that the average six-minute walk distance (6MWD) in both groups (HIAIT and MICT) before the start of the CR programs was no statistically significant between them (p>0.05). A significant increase in the 6MWD in both CR groups was found after the final of 12-week of CR program (p<0.001). The increase obtained in HIAIT group was higher than the increase observed in MICT group (14.53% vs. 10.6%, respectively). Conclusion: The 6MWT is a safe tool for assessing the effectiveness of CR interventions on functional capacity and mobility in different frail populations with CHF.

The possibilities for pharmaceutical care in the recovery of patients with post-COVID syndrome in the context of a patient-centered approach have been explored. The global COVID-19 pandemic has necessitated a reorientation of the concept of providing healthcare to patients with COVID and post-COVID syndrome in patient-centered treatment and rehabilitation. Maximum recovery in holistic practice adopts a broader view of the patient’s health, disease and treatment process. Applying a patient-centered approach to patients who have had a coronavirus infection will lead to many benefits, both in terms of the quality of health and pharmaceutical care, and in increasing their satisfaction with their quality of life.

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