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A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed for the simultaneous estimation of ondansetron combinations in solid dosage form with omeprazole and rabeprazole, respectively. The method involved separation of components by TLC on a precoated silica gel 60 F254 using a mixture of dichloromethane:methanol (9:1) as a mobile phase. Detection of spots was carried out at 309 nm and 294 nm for ondansetron with omeprazole and ondansetron with rabeprazole combinations, respectively. The mean retardation factor for ondansetron and omeprazole were found to be 0.42±0.02, 0.54±0.03, respectively while for ondansetron and rabeprazole, 0.41± 0.02 and 0.51±0.02, respectively. The linearity and range was 0.1 to 0.5 μg/spot for three drugs. The method was validated for precision, accuracy and reproducibility.

The mixed ligand complexes of the type [ML1L2]Cl2. Where M=Cr(III), Mn(II), Co(II),Ni(II) and Cu(II) with L1= Pyruvic acid thiosemicarbazone L2=Acetone semicarbazone, have been synthesized, by the reactions of metal chlorides with two different semicarbazones in 1:1:1 molar ratios. The resulting products have been characterized on the basis of elemental analysis, magnetic measurement, IR and Electronic spectra, conductivity measurement, thermal analysis, antimicrobial activities. The metal complexes show ratio 1:1:1 with metal, ligand L1 and ligand L2.The ligands are bonded through oxygen and nitrogen and sulphur to metal ion.

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