There are significant concerns about the transition process in this population. Given the expressed need for autonomy and a transition clinic, the basis for a smoother transition in the future has been laid.

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SULFHAPYRIDINE FOR CEREBROSPINAL FEVER M THE BRiTisH MEIDICAL JOURNAL epidemics should be treated with sulphapyridine in combination with either serum or antitoxin for further trial. Dosage with sulphapyridine may be increased with impLunity in subsequent trials and with the likelihood of improving results still fturther. Summary One hundred and sixty cases of cerebrospinal fever were treated in fouir groups: serum (50 cases), sulphapyridine (50 cases), sulphapyridine plus serum (30 cases), sulphapyridine plus antitoxin (30 cases). Satisfactory resLtIs were obtained, fatality rates for the groups being 38, 32, 26.6, and 20 per cent. respectively. The recovery rate was accelerated in the groups where sulphapyridine was emvloyedl. Blood cultUres were performed in 126 cases only; positive cultures were obtained in 100 cases, twenty-one of which ended fatally. Concentration of sulphapyridine in the cerebrospinal fluid was estimated, but the concentration appeared to have little if any relation to the dosage. No toxic reactions were experienced in any of the cases treated with sulphapyridine. We wish to thank Messrs. May and Baker for their courtesy in supplying sulphapyridine (M & B 693) free of charge for this test upon request. We also wish to thank the staff of the hospitals and laboratories, especially Dr. K. W. J. Lieu, for their cooperation. We are indebted to Mr. L. H. Barton for the estimations and also to Mr. Fanthorpe.

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