Gases with sufficient Lewis acidity or basicity form weak and reversible complexes with carefully selected ionic liquids. We have prepared ionic liquid complexes with PH3 and BF3 that provide large gas capacities in the liquid phase at low pressures.

Aus der Fluorierung von (I) geht das gegenüber Dimerisierung, O2, C12, Brz, I2 beständige, perfluorierte Alkylradikal (II) hervor, das jedoch mit F2 bei Zimmertemp.

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

The stability and uniformity of a radio-frequency (RF) discharge is limited by a critical power density. Beyond this critical power density, instability occurs in the form of physical changes in the plasma (such as contraction due to arcing). The RF discharge used in this study is the non-equilibrium Atmospheric Pressure Plasma Jet (APPJ ® ) developed by Apjet, Inc. This discharge is known to operate uniformly in helium gas. However, for some proposed applications such as surface modification, there is a need to operate with reactive gases such as O 2 . Our experimental studies show that addition of molecular gas to a discharge operating in helium increases its power density (W cm −2 ), until it reaches the critical unstable arcing limit. Moreover, an increase in the frequency of operation (from 13 to 27 MHz) allows the plasma to sustain higher molecular gas concentrations and power densities before instability occurs. Further, it is observed that this critical power density is dependent on the type of molecular gas added. These results provide a motivation for the development of a mathematical model that can provide insight into the causes of instability and potential methods of suppression. The two commonly studied modes of instability are (1) thermal instability (TI) and (2) α-γ -arc mode transition. For the APPJ ® discharge conditions, the development time scales of TI are much longer (∼1 ms) as compared with discharge oscillation period (∼100 ns). Hence, if the instability was indeed thermal, discharge frequency increase would have no consequence, contrary to experimental findings. A 1D fluid model based on the local field approximation is developed to study instability in APPJ ® discharge. The analysis of modeling results confirmed our hypothesis that the instability development actually takes place via breakdown of sheath i.e. α-γ -arc mode transition and not by TI.

Nitrogen has four binary fluorides: nitrogen trifluoride, tetrafluorohydrazine, difluorodiazine, and fluorine azide. There are numerous other nitrogen fluorine compounds, the most significant of which are the perfluoroammonium salts based on the NF + 4 cation. Of all the nitrogen fluorine compounds, only NF 3 has been of commercial importance. Nitrogen trifluoride is used as an etchant gas in the electronic industry and as a fluorine source in high power chemical lasers.