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Objectives: It is hypothesized that the risk of hypersensitivity reactions (HSRs) may be lower with ferric carboxymaltose than iron dextran because of its non-dextran carbohydrate moiety. This study compares the risk of HSRs between iron dextran and ferric carboxymaltose. Methods: This was a retrospective pharmacoepidemiological study with a case-population design covering 2008-2017. Global exposure data were estimated using IQVIA™ sales data. Spontaneously reported HSR data were retrieved from the World Health Organization database (VigiBase™) using different search criteria including: the Standardized MedDRA® Query (SMQ) 'Anaphylactic reaction'; type I-IV HSR terms; narrow terms for anaphylactic/anaphylactoid reactions; and cases with a fatal outcome. Results: Total exposure in 100 mg doses was 117.3 million for iron dextran and 84.2 million for ferric carboxymaltose. The relative risk (with 95% confidence interval) for ferric carboxymaltose versus iron dextran was 4.18 (3.88-4.50) for SMQ Anaphylactic reaction; 12.9 (9.90-16.7) for type I-IV HSRs; 1.72 (1.45-2.04) for anaphylactic/anaphylactoid reactions; and 1.92 (1.24-2.99) for death. Conclusion: The risk of spontaneously reported HSRs was consistently higher with ferric carboxymaltose than with iron dextran over the period 2008-2017. Thus, this study does not support that dextran-free intravenous irons are associated with fewer HSRs than iron dextran.

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of underweight (7/9 (78%)), healthy (28/46 (61%)), overweight (14/23 (61%)) and obese (6/12 (50%) p=0.642). Patients with >5% weight loss (13/101 (13%)) or suboptimal HGS (56/101 (55%)) were significantly more likely to be at nutrition risk using IBD-NST, MUST and SGA. Patients with suboptimal MAMC (10/66 (15%)) were not significantly more likely to be at nutrition risk using IBD-NST or MUST. Conclusion The IBD-NST identifies more patients with high nutrition risk and places less importance on BMI than SGA or MUST. Finally, we confirm that BMI is a poor indicator of HGS in IBD supporting a reduced importance in identifying nutrition risk. Further work is underway to test the repeatreliability the IBD-NST.