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INTRODUCTIONHypertensive pregnancy disorders complicate 10% of all pregnancies.1 WHO estimates that at least one woman dies every seven minutes from complications of hypertensive disorders during pregnancy. 2 The incidence of PIH is high among the women who have conceived for the 1st time.3 Preeclampsia (PE) is currently classified as a pregnancy-specific syndrome characterized by the presence of new-onset hypertension in a previously normotensive woman after 20 weeks of gestation with proteinuria. Eclampsia is classified as presence of seizures, non-attributable to other causes, in women diagnosed with PE. 4 If undetected, preeclampsia can lead to eclampsia which is one of the top five causes of maternal illness, infant illness and death. The risk of developing pre-eclampsia appears to be greater in women who have family histories of essential hypertension. 5Maternal endothelial dysfunction is considered as a classic hallmark of preeclampsia.6 Previous studies had stated that preeclamptic women had presented arterial ABSTRACT Background: Pregnancy induced hypertension is considered as the major cause of maternal and perinatal mortality. Even though occurrence of PIH is due to abnormal placentation, endothelial dysfunction plays a pivotal role in the genesis of the multisystem disorder that develops in pre eclampsia and eclampsia. Various studies have proved that hyperlipidemia is one of the major causes of endothelial dysfunction. Since ApoB/apoA-I ratio is a dyslipidemic indicator, the study was designed to determine ApoB/ApoA-I in PIH women and to analyse whether this ratio can be correlated with ED in PIH women. Methods: A cross-sectional analytical study involved normotensive, preeclamptic and eclamptic pregnant women with hundred subjects in each group. They were investigated for serum lipid profile, ApoA, ApoB, NO, MDA, FRAP in the 3rd trimester of pregnancy.

INTRODUCTIONHypertensive disorders are the common medical disorders in pregnancy. It has effects both on expectant mother and fetus. The impact of pregnancy induced hypertension (PIH) is very high in India and other developing countries.The incidence of PIH in India is about 7-10% of all antenatal admission. PIH is the appearance of hypertension of more than 140/90 mm of Hg after 20 weeks of gestation. When hypertension is associated with significant proteinuria it is called preeclampsia (PE). PE complicated by seizures is called eclampsia which is a major cause of maternal mortality. 1Endothelial dysfunction (ED) plays a focal role in the origin of the multisystem disorder that develops in PE. The mechanisms involved in the induction of ED are poorly understood. Pregnancy is associated with physiological changes such as increase in lipids from first to third trimester in order to satisfy energy and membrane ABSTRACT Background: Preeclampsia is a major cause of maternal and fetal/neonatal mortality and morbidity even in developed countries. Despite of extensive research, the etiology and pathogenesis of preeclampsia are not completely understood. Evidence shows that imbalance between angiogenic and antiangiogenic factor plays a pivotal role in the genesis of endothelial dysfunction which is considered as a hall mark in the development of multisystem disorder in pre-eclampsia and eclampsia. Abnormal lipid metabolism is a known causative factor for endothelial dysfunction. This study has been designed to determine the association between abnormal lipids and angiogenic, anti angiogenic balance in PIH (PE and E) women. Methods: Study group consisted of Normotensive pregnant women (N) preeclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for lipid profile and apolipoproteins, MDA, FRAP, TNF-α, sFlt-1, VEGF, PlGF, NO. Statistical analysis was done using ANOVA and pearson correlation analysis. Results: When compared to controls TC, TGL, VLDL, LDL, apoB, MDA, TNF-α, sFlt-1 levels were found to be significantly high and HDL, apoA, FRAP, VEGF, PIGF, and NO levels were significantly low in PE, E group. Eclamptic women showed a significantly high level of MDA, TNF-α, sFlt-1and low levels of FRAP, VEGF, PIGF, NO when compared to PE group. Conclusions: In PIH women, abnormal lipid metabolism is associated with angiogenic and antiangiogenic imbalance.