A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 microm on an active area of 2.67 mm x 2.67 mm, and in the zooming mode, temporal resolutions down to 8 micros on 64 randomly selected electrodes. The low-noise performances of the integrated amplifier (11 microV (rms)) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data.

In daily life, a person's gait-an important marker for his/her health status-is usually assessed using inertial sensors fixed to lower limbs or trunk. Such sensor locations are not well suited for continuous and long duration measurements. A better location would be the wrist but with the drawback of the presence of perturbative movements independent of walking. The aim of this study was to devise and validate an algorithm able to accurately estimate walking cadence and speed for daily life walking in various environments based on acceleration measured at the wrist. To this end, a cadence likelihood measure was designed, automatically filtering out perturbative movements and amplifying the periodic wrist movement characteristic of walking. Speed was estimated using a piecewise linear model. The algorithm was validated for outdoor walking in various and challenging environments (e.g., trail, uphill, downhill). Cadence and speed were successfully estimated for all conditions. Overall median (interquartile range) relative errors were -0.13% (-1.72 2.04%) for instantaneous cadence and -0.67% (-6.52 6.23%) for instantaneous speed. The performance was comparable to existing algorithms for trunk- or lower limb-fixed sensors. The algorithm's low complexity would also allow a real-time implementation in a watch.

Abstract-The presence of a secondary code in modern global navigation satellite system signals complicates the acquisition of these signals, because there is a potential sign transition between each period of the primary code. Some previous works proposed to use the parallel code search by performing the correlation over the primary code several times and then combining the results according to the secondary code chips. In this article, we will focus on this method and compare different hardware implementations, to determine if it is better to do the combinations before or after the correlations, and to compare serial and parallel architectures. In a second part, we will show a simple method that manipulates the local secondary code to rearrange the equations, which approximately halves the theoretical number of operations related to the secondary code correlation and the processing time for hardware implementations, without any impact on the sensitivity.

The acquisition of global navigation satellite system signals can be performed using a fast Fourier transform (FFT). The FFT-based acquisition performs a circular correlation, and is thus sensitive to potential transitions between consecutive periods of the code. Such transitions are not occurring often for the GPS L1 C/A signal because of the low data rate, but very likely for the new GNSS signals having a secondary code. The straightforward solution consists in using two periods of the incoming primary code and using zeropadding for the local code to perform the correlation. However, this solution increases the complexity, and is moreover not efficient since half of the points calculated are discarded. This has led us to research for a more efficient algorithm, which discards less points by calculating several sub-correlations.It is applied to the GPS L5, Galileo E5a, E5b and E1 signals. Considering the radix-2 FFT, the proposed algorithm is more efficient for the L5, E5a and E5b signals, and possibly for the E1 signal. The theoretical number of operations can be reduced by 21 %, the processing time measured on a * Corresponding author Email address: jerome.leclere@epfl.ch (Jérôme Leclère)Preprint submitted to Signal Processing July 2, 2013 software implementation is reduced by 39 %, and the memory resources are almost halved for an FPGA implementation.

The use of global navigation satellite system receivers for navigation still presents many challenges in urban canyon and indoor environments, where satellite availability is typically reduced and received signals are attenuated. To improve the navigation performance in such environments, several enhancement methods can be implemented. For instance, external aid provided through coupling with other sensors has proven to contribute substantially to enhancing navigation performance and robustness. Within this context, coupling a very simple GPS receiver with an Inertial Navigation System (INS) based on low-cost micro-electro-mechanical systems (MEMS) inertial sensors is considered in this paper. In particular, we propose a GPS/INS Tightly Coupled Assisted PLL (TCAPLL) architecture, and present most of the associated challenges that need to be addressed when dealing with very-low-performance MEMS inertial sensors. In addition, we propose a data monitoring system in charge of checking the quality of the measurement flow in the architecture. The implementation of the TCAPLL is discussed in detail, and its performance under different scenarios is assessed. Finally, the architecture is evaluated through a test campaign using a vehicle that is driven in urban environments, with the purpose of highlighting the pros and cons of combining MEMS inertial sensors with GPS over GPS alone.