Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of human PRV encephalitis diagnosed by the next-generation sequencing (NGS) of PRV sequences in the cerebrospinal fluid (CSF) of a patient. A male pork vendor developed fever and seizures for 6 days. NGS results showed PRV sequences in his CSF and blood. Sanger sequencing showed that PRV DNA in the CSF and PRV antibodies in both the CSF and blood were positive. MRI results revealed multiple inflammatory lesions in the bilateral hemisphere. Based on the clinical and laboratory data, we diagnosed the patient with PRV encephalitis. This case suggests that PRV can infect humans, causing severe viral encephalitis. People at risk of PRV infection should improve their self-protection awareness.
The fracture of battery materials is one of the main causes of battery degradation. This issue is further amplified in emerging solid-state batteries, where the more robust interface between the liquid electrolyte and solid electrode in conventional batteries is replaced by a brittle solid-solid interface. In this review, we summarize the observed fracture behavior in battery materials, the origin of fracture initiation and propagation, as well as the factors that affect the fracture processes of battery materials. Both experimental and modeling analyses are presented. Finally, future developments regarding the quantification of fracture, the interplay of chemo-mechanical factors, and battery lifespan design are discussed along with a proposed theoretical framework, in analogy to fatigue damage, to better understand battery material fracture upon extended cycling.
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