Trans‐[13,14‐14C2]‐Retinoic acid has been synthesized by condensation of β‐ionylideneacetaldehyde and 14C‐labeled methyl senecioate in the presence of potassium amide in ether. A convenient synthesis of the key intermediate, methyl (diethoxyphosphinyl)‐[2‐14C]acetate, is also described.

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Several quinoxaline, benzimidazole, and alkoxybenzene derivatives containing the novoldiamine function, either as a side chain or incorporated as a ring constituent, were synthesized as potential causal prophylactic antimalarial agents. 1‐(5‐Dimethylamino‐2‐pentyl)‐5‐methoxy‐benzimidazole (2a) was shown to have the desired prophylactic activity in the preliminary sporozoitc‐indueed Plasmodium gallinaceum test.