No abstract

Atopic dermatitis is a chronic inflammatory dermatoses, pruritic and relapsing, with variable density in which attacks mostly patients in pediatric age group. Therefore, the disease can cause a series of psychological and social damage because of its consequences at the family’s routine. Thus, the disease gets involved at the daily activities and interpersonal relationship. In summary, this study objective is to review articles about atopic dermatitis’ impact on the life quality of pediatric patients and their caregivers, using integrative review and literature's descriptive as a method, with a quality approach, at SciELO and Google Scholar data base in the month of June of 2021 with the words: “atopic eczema”, “children”, “relatives” and “welfare”. It was found 200 articles written in English, Portuguese and Spanish, published between 2012 and 2021 that had public access. From this number, 11 studies were selected to compose this review’s data base. In conclusion, the atopic dermatitis negatively affects the daily life of pediatric patients and their caregivers. The discomfort caused by the pruritic eczema adds to sleep deprivation and affects the children’s development at school, family and psychosocial life. The worst of this disease is related to bad quality of life index. A better understanding of atopic dermatitis’ impact can positively affect the patient’s frequent treatment and therapeutic strategies.

A hanseníase é uma patologia infecciosa crônica, causada pelo Mycobacterium leprae, ou bacilo de Hansen, ao qual é uma bactéria gram-positiva resistente e que pode infectar os nervos periféricos. Sendo assim, a hanseníase é considerada uma doença com um alto poder infeccioso e baixo nível patogênico, e por isso, associada a 95% de imunidade na maioria das populações de ocorrência. Nesse contexto, o modelo mais eficaz a ser adotado para o controle da hanseníase baseia-se na complementariedade das ações; com início no diagnóstico precoce, tratamento especializado e contínuo dos casos diagnosticados, prevenção de incapacidades, vigilância aos contatos domiciliares do paciente, até a alta por cura. Contudo, alguns pacientes podem apresentar reação hansênica tipo 1, reação essa que ocorre frequentemente logo após o início do tratamento, apresentando reações inflamatória granulomatosa e necrose tecidual concomitante ao possível comprometimento neurológico sintomático. Em contrapartida alguns pacientes podem apresentar a reação hansênica tipo 2, reação essa que ocorre geralmente durante e após o tratamento e é determinado pela manifestação de nódulos na pele de aparecimento súbito. Assim, o tratamento da hanseníase é poliquimioterápico, ambulatorial e utiliza esquemas terapêuticos padronizados, preconizados pela Organização Mundial da Saúde. Valendo lembrar que a hanseníase é uma doença curável, controlável e de tratamento gratuito.

Hepatitis C is an inflammatory process caused by a virus of the genus Hepacivirus. It can be triggered acutely or chronically, the latter being predominant. Chronic hepatitis C (CHC) has a worldwide prevalence in about 1% of the population. Hepatitis C virus infection (HCV) has a diverse genetic variety, which makes its elimination difficult.The present work emerges as a need to understand the mechanisms of defense action against HCV in the human body. The study was based on a literature review, based on research in articles from the SciELO and PubMed platforms, using the descriptors hepatitis C, genetics and immune system associated through the Boolean operators OR and AND. In the end, 15 articles were selected that guided the research of the work. In research, it was found that the virus infection can present in the acute phase or in the chronic phase, in which most cases tend to progress from an acute infection barely detectable by the immune system to a persistent chronic infection. In addition, it was observed that T cells during the chronic phase have their ability to resolve reduced, because, in the acute phase, because of the virus, a large variability does not allow T cells to create neutralizing antibodies or memory cells, therefore, when they present the chronic stage, it causes these defense cells to collapse. Much progress has been made in understanding the immune mechanisms that HCV stimulates, however there are still many gaps that need to be closed.