In this work, a study of the protective properties of a new hydroxy derivative of chalcone was carried out in comparison with a water-soluble analogue of vitamin E - trolox. The inhibitory activity of the compounds was evaluated on a model system of the long-term process of lipid peroxidation in Siberian sturgeon sperm without and with the addition of a cryo-medium. The prolonged antioxidant activity of chalcone, comparable with the action of the reference compound, was established. An increase in the time of sperm motility in the presence of the compounds under study, while maintaining a survival rate of 100%, allows us to consider the hydroxy derivative of chalcone as an potential cryoprotectant.

The influence of new phenolic derivatives of pyrrolidine on the quality of native sturgeon sperm and on the fertility of eggs was assessed in comparison with the well-known antioxidant - ionol. The high efficiency of (L)-1-(2-((1-hydroxynaphthalen-2-yl)thio)acetyl)pyrrolidine-2-carboxylic acid was shown, the addition of this compound increases the time of forward movement of spermatozoa by 2.2 times relative to the control and an increase in the percentage of fertilization and hatching of prelarvae by about 1.5 times. The results obtained indicate the need for additional studies to establish the cryoprotective activity of these derivatives under conditions of deep freezing and defrosting.