Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson’s disease, Alzheimer’s disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement has been found in the treatment of the same. Moreover, it was proved that natural products can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of neuroprotective agents. This review will target the therapeutic potential of various phytochemicals which shows neuroprotective action.

Terminalia catappa Linn. belonging to family Combretaceae is well known plant due to its nutritional fruit, bark, leaves and roots which are having medicinal properties. The various phytochemicals which are present in it are such as gallic acid, ellagic acid, corilagin, alkaloid, flavonoid, protein, phytosteroids, phenol and carotenoids are isolated form the different parts of the plant in various solvent systems. These isolated compounds have found to be possess numerous pharmacological properties such as antioxidant, antidiabetic, antimicrobial, antifungal,  antinociceptive, hepatitis treatment, hypocholesterolemia, immunomodulatory, anthelmintic, antiviral, antiaging, anti-inflammatory, anticancer, anti-tumor, hematological, anthelmintic, aphrodisiac, wound healing. These all pharmacological activities cumulatively enhanced its traditional value and uses. In this review paper, the different pharmacological activities and their benefits are explored which are exhibited by different phytoconstituents present in different parts of the plant.

An injury to the human body is classified as a wound if it results in a cut or a break in the skin. Depending on the depth of the skin layer, a wound can either be limited to the epidermal layer, which heals via re-epithelialization without the need for skin grafts, or full-thickness wounds, which result in the loss of both the epidermis and dermis (FTW). A full-thickness wound cannot heal on its own and needs a skin graft or tissue regeneration product to heal quickly. This paper provides a comprehensive overview of the properties of electrospun nanofibers and their application as skin regeneration products rapid healing of the full-thickness wound. The paper first introduces the skin, its layers, and various problems associated with human skin. In the next part, a wound is discussed in terms of acute and chronic wounds. Primary, secondary and tertiary clinical wound healing has also been discussed. The next part briefly introduces the four different phases of healing, i.e. hemostasis, inflammation, proliferative and maturation of newly deposited collagen into tissues. The effect of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) on reactive oxygen species, reactive nitrogen species and reactive sulphur species, and their effect on healing time was discussed. The electrospinning process's evolution and setup, properties of electrospun nanofibers, a component of electrospinning solution, and various parameters affecting electrospinning were discussed. Application on nanofiber scaffold in terms of drug delivery and tissue regeneration was highlighted. In the end, improvement in the existing nanofibrous scaffold was briefly highlighted.

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