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The ability to induce labour has been of interest of many societies, from the primitive to the ancient to the modern era. Mostly labour sets in spontaneously but for various obstetrical and medical indications it needs to be induced when the benefits to either the mother or the foetus outweigh those of continuing the pregnancy. There are many indications for induction of labour in which PROM (Premature Rupture of Membrane) is one of them. The onset of labor in human is a complex biological phenomena controlled by multiple regulatory mechanism. In recent times, prostaglandins analogue are the most widely used agents for induction of labor. This study is done to compare the efficacy and safety of misoprostol and oxytocin for induction of labour in PROM at term. Method: A total of 200 pregnant women were taken as sample in my study. 100 each in misoprostol (Group A) and oxytocin (Group B) respectively. The randomisation was done by single random sampling. Group A received oral misoprostol and Group B received oxytocin as per the dose decided. The results of the study were compared and decided on the basis of age, gestational age, gravida, Bishop's score, induction delivery interval, mode of delivery, maternal and fetal side effects. Result: The present study shows that although Induction -Delivery Interval is more in miso post, but is comparable to i.v. oxytocin. Maternal side effects and neonatal outcome were similar with both drugs. Conclusion: Misoprostol and oxytocin both are equally efficacious and safe drugs and either of the drugs can be used for induction in PROM.