Objective: Teenage is the time of shaping health behavior and preventing postural defects and improving respiratory fitness. The teenagers possess insufficient knowledge of their respiratory system. Postural defects are commonly seen among teenagers due to lack of physical activity and poor postural habits which can lead to non-harmonious development of organs and affect respiratory system as well. For efficient respiratory function, moderate-intensity exercises with posture correction would be useful. There is a paucity of literature showing the effect of posture correction and moderate-intensity exercises on respiratory system in teenagers, hence, this study would be helpful to analyze the same. The objectives of the study were to find out the effect of posture correction exercise on respiratory system in teenagers and to find out the effect of moderate-intensity exercises on respiratory system in teenagers. Materials and Methods: The study was carried out in Karad area. The subjects were selected according to the inclusion and exclusion criteria. A total of 35 subjects were participated in this study. Prior consent and assent form was taken. The aim and procedure were explained to the subjects in their preferred language before data collection. Pre- and post-assessment was done by 6 min walk test for respiratory function and flexicurve was measured using flexible ruler to recognize spinal postural defect. Peak flow meter was used to measure lung function. Results: In a conducted study, 6 min walk test, peak flow meter, and flexicurve showed statistically significant difference between pre- and post-treatment values. Conclusion: On the basis of the result of the study, it can be concluded that posture correction and moderate- intensity exercises help in improving respiratory function in teenagers.

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To study the Effect of Physiotherapy on Fatigue Psychological Stress in Cancer Patients during the Course of Chemotherapy. Subjects fulfilling the inclusion and exclusion criteria were included. Prior consent was taken and assessment of their fatigue, stress level and pain was done using the brief fatigue inventory, Cohen perceived stress scale and brief pain inventory. Based upon the findings, a tailor made protocol was given to the patients, wherein 3 sets of each exercises 5times a week for a month’s duration had to be followed. The exercises were altered as per the patients’ requirements and capability. Each session conducted was of 35-45min duration which began with Warm-up Exercises including Stretching for 10min, followed by 6 Minute Walk for 6minutes, Harvard Step for 3 minutes and the session was concluded with a Relaxation period of 20minutes. For relief of pain, TENS was given during the Relaxation period. After the 6minute walk, patient’s exertion was checked by the Borg Scale. The exercises were prescribed according to FITTs principle. Statistical analysis was done using unpaired t test. In this study, pre-intervention Brief Pain Inventory was 71.90±12.33 and post-intervention was 61.03±11.47. In Brief Pain Inventory statistically extremely significant difference and decrease in pain post intervention with (p< 0.0001) with t= 7.028. Pre-intervention Brief Fatigue Inventory was 53.83±11.03 and post-intervention was 41.78±13. In Brief Fatigue Inventory statistically extremely significant difference and decrease in fatigue post intervention with (p=<0.0001) with t=9.57. Stress assessment by Cohen Perceived Stress Scale was 21.71±2.27pre treatment and 19.86±2.23 post treatment. In Cohen Perceived Stress Scale, statistically extremely significant difference and decrease in stress level after treatment with (p=<0.0007) with t=4.998. Pre-treatment Rate of perceived exertion was 12.49±3.23 and post treatment was 10.34±2.94.In Rate of Perceived Exertion statistically significant difference and decrease in exertion level post treatment with (p=<0.0007) with t=8.945. Thus the above concludes that physiotherapy had significant improvement clinically and statistically on fatigue and stress in cancer patients undergoing chemotherapy. So this study accepts the alternate hypothesis.

To investigate efficacy and safety of cetuximab combined with neo adjuvant chemotherapy regimen in patients with unresectable colorectal liver. This was a prospective trial with rate of Ro liver metastases resection as primary end point. Between January 2010 and December 2014, 46 patients with unresectable liver metastases from colon or rectum were enrolled. Patients received Cetuximab along with neoadjuvant chemotherapy where 34 (74 %) and 12 (26 %) patients received FOLFOX and FOLFIRI, respectively. They were assessed for response after 2-3 cycles by CT scan. Patients with resectable disease were offered liver surgery within 3-6 weeks of the last treatment cycle. The primary end point was resection rate of liver metastases, which was evaluated in all patients. Secondary end points were response rate according to Response evaluation criteria in solid tumors (RECIST) criteria, perioperative morbidity and mortality. An objective response was observed in 28 (60.9 %) patients. Seven (15.2 %) patients were reported radiologically to have a complete response (CR); 21 (45.7 %) patients had radiological partial response (PR). An additional 12 patients (26.1 %) demonstrated stable disease (SD) and only six patients (13.0 %) had disease progression (PD). Microscopically complete resections (R0 resection) was performed in all 28 patients (60.9 %). The most frequent toxicities were skin rash and diarrhoea. There was no operative mortality. Chemotherapy with cetuximab yields high response rates compared with historical controls, and leads to significantly increased resectability. Complete resection of previously unresectable colorectal liver metastases can be performed with minimal morbidity and mortality. This therapeutic strategy involves a multimodal approach.

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