Background: General anaesthesia is an altered physiological state characterized by reversible loss of consciousness, amnesia ,analgesia and some degree of muscle relaxation.no single agents can produce these desired effects.It involves inhalational anaesthetics,induction agents, opioids, neuromuscular blockers. Combination of all these drugs will produce the optimal anaesthesia which is known as balanced anaesthesia. Airway management is an integral part of general anaesthesia, which includes direct laryngoscopy and endotracheal intubation. Objective: To compare the efficacy of two different doses of esmolol to attenuate the hemodynamic response during laryngoscopy and endotracheal intubation. Methodology: The present comparative cross sectional study was conducted by the Department of Anaesthesia at Vinayaka Missions KirupanandaVariyar Medical College and Hospital, Salem from December 2019 – May 2021. The comparative study was done between two study groups with Group A receiving 50 mg of IV Esmolol and Group B Receiving 100 mg of IV Esmolol, A total of 60 study patients who met the inclusion criteria were included in the Study and divided into 30 subjects in each group. Results: The mean age of the patients in Group A was 37.3 (12.0) years with a minimum of 18 years and a maximum of 60 years.