No abstract

Vesicles prepared from self-assembly of hydrated non-ionic surfactants molecules are called niosomes. These types of vesicles were first reported in the cosmetic industries. Niosomes exhibit more chemical stability than liposomes (a phospholipids vesicle) as non-ionic surfactants are more stable than phospholipids. Non-ionic surfactants used in formation of niosomes are polyglyceryl alkyl ether, glucosyldialkyl ether, crown ether, polyoxyethylenealkyl ether, ester-linked surfactants, and steroid-linked surfactants and a spans, and tweens series. Niosomes preparation is affected by processes variables, nature of surfactants, and presence of membrane additives and nature of drug to be encapsulated. This review article presents an overview of theoretical concept of factors affecting niosome formation, techniques of noisome preparation, characterization of niosome, applications, limitations and market status of such delivery system.

No abstract

A simple and convenient procedure for the deoximation with 0.5 M aqueous hypochlorite at ambient temperature is reported. Ketoximes yielded ketones quantitatively and aldoximes yielded aldehydes only at pH 5—7 or mixture of aldehydes and carboxylic acids at pH 10—11.

Background: Alzheimer’s disease is an irreversible, progressive brain disorder manifested with symptoms like loss of memory (known as dementia), personality changes, loss of cognition, impaired movement, confusion, deteriorated planning and thought process. Neurodegeneration in Alzheimer’s disease is the result of deposition of protein beta-amyloid that forms plaques and another protein called tau, forming tangles that prevent proper functioning of nerve cells in the brain. Methods: The goal of the review was to comprehensively study the utilization of nanotechnology and the role that carbon nanotubes can play as a drug delivery system for amelioration of Alzheimer’s disease. Results: Nanotechnology is one of the most researched domains of modern science. It contributes significantly to therapeutics by facilitating drug therapy to reach the target sites, which are otherwise difficult to reach with conventional drug delivery systems. Carbon nanotubes are the allotropes of carbon in which several carbon atoms bind with each other to form a cylindrical or a tube-like structure. The carbon nanotubes possess several unique qualities, which confers them with a high potential of being utilized as an efficient drug delivery system. They offer high drug loading, can readily cross the toughest biological barriers like BBB. Carbon nanotubes also facilitate the passage of drugs to the brain via the olfactory route, which further helps in restoring normal autophagy, thus preventing the elimination of autophagic chemicals. They can carry a vast range of cargos, including drugs, antigens, genetic materials, and biological macromolecules. Conclusion: Carbon nanotubes are highly promising drug delivery system for anti-Alzheimer’s drugs. They have potential of overcoming the various biological barriers like BBB. However, more extensive research is required so as to set up a firm base for development of advanced commercial products based on carbon nanotubes for treatment of Alzheimer’s disease.