Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential

Biswal, Sudershan; Murthy, Padala Narasimha; Sahu, Jharna; Sahoo, Prabhat K.; F, Amir

doi:10.37285/ijpsn.2008.1.1.1

Cited by 36 publications

(25 citation statements)

References 26 publications

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“…This might be due to the merging of vesicles, which occur owing to molecular movements with the passage of time. 37 Cholesterol has been used in niosomes to enhance stability. In general all preparations were found stable.…”

Section: Resultsmentioning

confidence: 99%

<p>In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug</p>

Rasul

Khan

Rehman

et al. 2020

IJN

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Background: Cyclosporine A (CsA) is an exceptional immunosuppressant used for the treatment of immune disorders. Niosomal vesicles are promising drug carriers that are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. The objective of the study was to formulate combined nonionic surfactant based vesicles and to evaluate their in vitro characterization, release studies and in vivo studies. Materials and Methods: Five niosomal formulations (F 7 to F 11) were prepared using the thin film hydration method. The molar ratio of cholesterol and non-ionic surfactant taken was 1:1. In formulation F 10 , the combination of surfactants Span 20 and Brij 35 was used. The niosomes were characterized by zeta sizer and SEM for particle size analysis, in vitro drug release and stability studies. The pharmacokinetic studies were conducted on healthy albino rabbits. Results: The size of niosome was found in the range of 427.1 nm to 972.3 nm. SEM image of optimized formulations F 10 exhibit the spherical nature of niosomal vesicles. DSC thermograms of niosomal formulations exhibited a broadened endothermic peak. The stability study exhibited that all formulations are stable and negligible change of vesicle size and entrapment was observed with time. The percentage drug release was significantly higher as compared to CsA plain dispersion for all niosomal formulations at pH 1.2 and 7.4. The release kinetic behavior showed that all preparations were best described by zero order and can release active ingredient in a sustained manner. The pharmacokinetic data showed the test formulation (F10) possessed greater bioavailability as compared to the reference formulation (CsA aqueous dispersion). Conclusion: The formulation F 10 demonstrated a comparatively more delayed rate of release with enhanced dissolution as compared to a single surfactant scheme. The F 10 formulation can be a remarkable nanotechnology for prolonged delivery of CsA orally with improved dissolution profile and bioavailability.

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Section: Resultsmentioning

confidence: 99%

<p>In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug</p>

Rasul

Khan

Rehman

et al. 2020

IJN

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“…They may be unilamellar or multilamellar depending upon the method used for their preparation. In recent years, niosomes have been extensively studied for the potential to serve as carriers for delivery of drugs, antigens, hormones, and other bioactive agents for an extended period of time or to a specific organ of the body [ 7 , 8 ]. In the present study, TDF loaded niosomes were prepared and evaluated for their in vitro and in vivo characteristics in an attempt to improve the oral bioavailability of the drug and also to extend the drug release for prolonged period of time.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement

Kamboj

Saini

Bala

2014

The Scientific World Journal

111

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Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability of tenofovir disoproxil fumarate (TDF), an anti-HIV drug. Niosomes were formulated by conventional thin film hydration technique with different molar ratios of surfactant, cholesterol, and dicetyl phosphate. The formulated niosomes were found spherical in shape, ranging from 2.95 μm to 10.91 μm in size. Vesicles with 1 : 1 : 0.1 ratios of surfactant : cholesterol : dicetyl phosphate with each grade of span were found to have higher entrapment efficiencies, which were further selected for in vitro and in vivo studies. Vesicles formulated with sorbitan monostearate were found to have maximum drug release (99.091%) at the end of 24 hours and followed zero order release kinetics. The results of in vivo study revealed that the niosomes significantly enhanced the oral bioavailability of TDF in rats after a dose of 95 mg/kg. The average relative bioavailability of niosomes in relation to plane drug solution was found to be 2.58, indicating more than twofold increase in oral bioavailability of TDF. Significant increase in mean residential time (MRT) was also found, reflecting release retarding efficacy of the vesicles. In conclusion, niosomes could be a promising delivery for TDF with improved oral bioavailability and prolonged release profiles.

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“…In addition, span 60 has better stability compared with other surfactants [8]. Niosome products were also generated using cholesterol to form stiffness and prevent leakage of the vesicles so that the rows of lipid molecules could be packed in the lipid bilayers of niosome vesicles.…”

Section: Fig 1: Chromatogram Of Betel Leaf Essential Oil Components mentioning

confidence: 99%

Stability of Anti-Acne Niosome Gels Containing Betel Leaf (Piper Betle L.) Essential Oil

et al. 2017

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Objective: Formulation, antibacterial activity, and stability tests of niosomal gels containing betel leaf (Piper betle L.) essential oil as an anti-acnetreatment were carried out. Niosome vesicular carriers provide drug delivery through the topical and transdermal routes. The aim of creating theniosome preparation was to increase the transfollicular penetration and improve the stability of the gel.Materials and Methods: Betel leaf essential oil extraction was performed using the steam distillation method, and essential oil compoundidentification was completed using gas chromatography–mass spectrometry. The niosome formulations were generated with two cholesterol–surfactant amount ratios, specifically, 1:1 (F1) and 1:2 (F2; w/w). The niosomes were evaluated, including the entrapment efficiency test, usingultraviolet-visible spectrophotometry; particle size analysis was performed using a particle size analyzer; and the vesicle morphology test wasconducted using transmission electron microscopy. The niosomes were made into a gel using 0.5% carbopol 940 as the gelling agent. The niosomegels were evaluated for their organoleptic properties, pH, viscosity, antibacterial activity against Propionibacterium acnes, and stability for 12 weeksat three different storage temperatures, namely, low temperature (4±2°C), room temperature (28±2°C), and high temperature (40±2°C).Results: The test results showed that the F2 niosome gel was more stable than the F1 gel was, while the antibacterial activities of the F1 and F2niosome gels did not differ significantly.Conclusion: The niosomal gel preparations’ inhibition of the growth of P. acnes bacteria was decreased compared with that of the essential oils.

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Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential

Cited by 36 publications

References 26 publications

<p>In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug</p>

<p>In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug</p>

Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement

Stability of Anti-Acne Niosome Gels Containing Betel Leaf (Piper Betle L.) Essential Oil

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