The objective of this study was to evaluate various physical and mechanical properties of experimental particleboard panels made from Asian giant bamboo (Dendrocalamus asper). Single layer panels having a density level of 0.75 g/cm3 from coarse and fine particles were used within the scope of this study. Thickness swelling, water absorption, surface roughness, and wettability characteristics of the samples were tested as physical properties while bending, internal bond strength, and screw withdrawal strength of the panels were considered for their mechanical properties. Resistance of the panels against termite and fungus were also determined. Based on the findings in the work both physical and mechanical properties of the panels made from coarse particles resulted in higher values than those made from fine particles with the exception of their internal bond strength. It appears that using fine particles in the panels enhanced their overall surface quality as well as wettability. Regarding biological deterioration of the samples, those made with coarse particles had better resistance. It seems that giant bamboo as a non-wood lignocellulosic species would have potential to be used as raw material to the manufacture value added particleboard with accepted characteristics.