Pyridazinones are important nitrogen-rich heterocyclic core that has been driving the substantial medicinal interest due to their wide range of biological activities. This privileged scaffold forms a central core in numerous potent compounds, which results in the development of novel anticancer drugs with fruitful biological activities. The current review article summarizes the progressive development of novel pyridazinone derivatives that are targets for numerous receptors such as C-met kinase inhibitors, PARP inhibitors, Tubulin polymerization inhibitors, Dihydro folate reductase inhibitors, B-Raf inhibitors, Bruton tyrosine kinase inhibitors, FER tyrosine kinase inhibitors, and fibroblast growth factors receptors. It features the various simple techniques for the synthesis of pyridazinones and also highlights the mechanistic insights into the anticancer properties of pyridazinone derivatives.

In current times, all major discoveries are believed to occur at the intersections of various fields of science. In such a manner, perhaps the main creative region joining material science, biology and medication is the utilization of microwave advances. In such a way, the motivation behind this work was to explain the useful conceivable outcomes of diagnostic, analytical, synthetic and therapeutic microwave advancements. The related exploration and uses of microwave (MW) science are the arising methodologies of modern energy-based green science, on a nuclear and atomic self-aggregating level. As microwaves develop the synthetic response, they have the potential to greatly impact the chemical reaction. This technology has advanced its utilization in the field of research technology, chemical synthesis, diagnostic chemistry, wastewater treatment, and material science. This article cumulates the various available microwave synthesizers in the market with their pros and cons alongside their wide applications.