An important reason for investigation using plants for nanotechnological research is due to their easy availability as well as applications in various ailments. Silver nanoformulation can be synthesized using whole plant extract or bioactive of that particular plant. In addition, plant extracts or bioactive of the plant may act both as reducing agents and stabilizing agents in the synthesis process of nanoformulation. The therapeutic effect of plant extract is hindered because of its instability, poor solubility, and low bioavailability. So, nowadays, researches have been carried out for improving all these properties including sustainability through silver nanotechnological approach. The major advantage of green synthesis using plant extracts is that, organic solvents and other excipients are not used because the plant phytochemicals are involved directly in the reduction of the ions and formation of silver nanoparticles. The present review provides an updated knowledge on mechanism of green synthesis of silver nanoparticle and their mechanism of action as antibacterial and anticancer activities.

Background: Around 1.5 billion people in the world were affected by complex neurological disorders and the figure is increasing alarmingly due to unsatisfactory clinical outcomes. To date, no conventional formulation is able to show a promising effect on the control or prevention of neurodegeneration. However, Nano delivery tools have shown better penetration and profound action on the targeted area of the brain. Methods: Although existing Nano therapeutic approaches are abundant but would not reach the clinic due to their improper bioavailability, BBB restricts its entry and causes improper biodistribution, so it’s a challenge to use certain bioactive as a potential therapy in neurodegenerative disorders. Hybrid nanocarriers are nano-vesicular transported systems, which could be utilized as carriers for the delivery of both hydrophilic and hydrophobic compounds. Available patents on nanodelivery for therapeutic approach will also include in this review. Results: Hybrid Nano delivery system may provide good stability to polar and nonpolar compounds and improve their stability. Conclusion: This manuscript updates the available findings on the Nano vesicular system to deliver drugs for neurodegenerative disorders.

The current learning was intended to analyze about the important phytoconstituents of methanolic fraction of Haldina cordifolia leaves extract. Qualitative extraction of Haldina leaves was prepared using Methanolic extract. H cordifolia leave extract confirms presence of Flavanoids, Alkaloids, phenols, saponins, anthraquinone, Phytosterols, coumarins and anthocyanins, which was confirmed from the TLC analysis. The FT-IR spectrum confirmed presence of alkyl, methyl, ether, amino, alkene, alcohol, carboxyl and carbonyl groups. UV spectral reports indicate presence of unsaturated groups and hetero atoms such as S, N, and O [8]. The absorption spectrum for H. cordifolia extract shows five identifying peaks and confirms presence of organic chromophores and variety of functional groups within the H. cordifolia extract. LC-MS analysis data suggests existence of hydroxyl coumarins compounds namely scopoletin , isoscopoletin , umbelliferone and phytosterols like ß- sitosterol,epiglobulol, campesterol and Caryophylene oxide etc., that can be considered for antimicrobial activity and it might largely contribute in action againest multidrug resistant microbes. Keywords: IR-spectroscopy, LC-MS, Scopoletin, Umbelliferone, ß-sitosterol and Campesterol.

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