Background: Poisoning with organophosphorus (OP) compounds are frequent because OP are widely used as insecticide or pesticide. OP compounds exert inhibition on acetylcholinesterase (AChE) activity by irreversibly binding to the catalytic site of the enzyme. The inhibition of AChE leads to hyperstimulation of muscarnic and nicotinic receptors due to excess of acetylcholine (ACh). Methodology:Various quinolin-2(1H)-one fused oxazole were synthesized by condensation and cyclization of chalcones with hydroxylamine hydrochloride in presence of piperidine. Synthesized compound were tested for in vitro reactivation of chlorpyrifos and methyl parathion inhibited AChE enzyme using pralidoxime (2-PAM) as standard reference. Result:Among the synthesized compounds, the compound 3b, 3f, 3g, and 5a have showed promising activity as compared to standard against chlorpyrifos inhibited AChE. However, 3f and 3gshowed good activity as compared to standard against methyl parathion inhibited AChE. th Conclusion: The derivatives having nitro and chloro substitution at 4 position gave potent activity against both OP compounds as compared to standard at concentration 0.001 M. Moreover, these quinolone fused oxazole seem to be very promising because of their sufcient reactivation potency at lower concentration-3 (10 M).

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Background Plants have been proven to be offering a wide number of medicinal uses. Mimusops elengi plant is rich in phytoconstituents present almost in every part of the plant. Roots are the parts on which minimum work has been done.Objective The objective of the present study was a preliminary evaluation of physicochemical and free radical scavenging activity of Mimusops elengi L. root. Methods Many standardization parameters like extractive values total ash value water-soluble ash value and acid insoluble ash moisture content and loss on drying LOD of Mimusops elengi L. root were analyzed. The total phenolic content TPC and total flavonoid content TFC were measured. Free radical scavenging FRS activity was evaluated by assessing DPPH scavenging activity.Results The results of phytochemicals screening of hydroalcohol extract revealed the presence of various secondary metabolites including alkaloids flavonoids saponins sterols and tannins. The amount TPC and TFC were found to be 21.63plusmn0.0663 mg of gallic acid equivalent weightg of extract and 159.0 plusmn 0.9 mg of quercetin equivalent weight g of extract respectively. The extract showed potent FRS activity IC50 value of 96.13 microgmL.Conclusions The present study revealed Mimusops elengi L. Root contains most potent antioxidant agents and has significant FRS activity.nbsp

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The present work was done to study qualitative investigation of extractability of the useful compounds from Aeglemarmelos leaves via supercritical fluid extraction technique (SFE) and to evaluate antihyperlipidemic activity of Aeglemarmelos(Am).The obtained extract and fractions were treated on Triton induced rat models and the results showed lowering the lipid profile levelin the experimental models by in-vivo methods. The fractions of Aeglemarmelos(AmF1) also exhibited excellent anti hyperlipedimic property at 3 rd week and also lowering the serum cholesterol, triglycerides in Triton induced rats. The most important ingredients present in plant communities turn out to be alkaloids, terpenoids, steroids, phenols glycosides and tannins are responsible for monitoring the normal lipid profile in Triton induced rats due to LA of lecithin acetyl transferase (LCAT), which regulates lipids concentration. The LCAT plays a key role in the incorporation of free cholesterol into HDL (this may increase HDL) and transferring it back to VLDL and LDL which are taken back later in liver cells.The changes in the level of serum lipids in experimental rats areillustrated in (Table 1). The total Cholesterol, TG1, LDL and VLDC significantlydecreased (P<0.001) and simultensely there is increase in level of HDLs.Supercritical Fluid extraction of leaves of Aeglemarmelos(Am)possess significantantihyperlipidemic activity as compared to control group.