BACKGROUND Endoscopic Retrograde Cholangio-Pancreatography (ERCP) is a technique that uses a combination of luminal endoscopy and fluoroscopic imaging for diagnosis and treatment of pancreato-biliary system disorders. ERCP also has its own adverse effects which can be mild to severe and even life threatening. 1,2 The common side effects of ERCP are: • Pancreatitis. • Haemorrhage. • Perforation. • Cholangitis. In this study, we are going to assess the role of prophylactic octreotide in preventing ERCP induced pancreatitis. The objectives of the study were-1. To find out the incidence of post-ERCP pancreatitis. 2. To evaluate the role of octreotide in preventing post-ERCP pancreatitis.