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A new series of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives was synthesized to study the effect of a hydrophobic unit, hydrogen bonding domain and electron-donor group on the compounds' anticonvulsant activity. The structures of the synthesized compounds were confirmed by their spectroscopic data and elemental analysis. All compounds were evaluated for their anticonvulsant activity in two animal models of seizures, viz. maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). The compounds were also evaluated for neurotoxicity. Compounds 4g, 4i, 5g and 5i exhibited excellent anticonvulsant activity in both animal models of seizure.

Background Nanotechnology's rapid development has been in great demand, particularly for silver nanoparticles, which are useful in a variety of industries including medicine, textiles, and home appliances. Silver nanoparticles are extremely essential due to their unique physicochemical and antibacterial properties, which can be used in a variety of applications. Green synthesis is an environmentally friendly alternative to conventional synthesis because it uses fewer chemical reagents and lowers temperature and pressure. Aloe vera and Thuja orientalis have a wide medical use because it contains a large number of compounds derived and was decided to use for the synthesis of nanoparticles. Main text The combination of silver nanoparticles has a wide range of applications, which has encouraged researchers to focus on the methods for the synthesis of silver nanoparticles from Aloe vera and Thuja orientalis leaves extract, characterization techniques of synthesized silver nanoparticles, and evaluation of their antimicrobial and antifungal activities. The synthesized AgNPs can be characterized by using various analytical techniques including UV–visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), etc. The various types of silver nanoparticles, various strategies for silver nanoparticle synthesis, nano-based drug delivery systems, taxonomy and chemical constituents of Aloe vera and Thuja orientalis plants, the general mechanism of action of silver nanoparticles in bacteria, and various applications of silver nanoparticles have also been discussed. Conclusion This review covers a wide range of research on silver nanoparticles to gain a better understanding of their physicochemical feature characterization, production, mechanisms of action, and applications. Various AgNP factors, such as size, surfactant, and structural shape, influence the unique physicochemical properties of these nanoparticles. Even though there are a variety of ways to make AgNPs, green synthesis has a high yield and biocompatibility because it uses natural agents and harmless chemicals. In this paper, we describe the green manufacture of silver nanoparticles utilizing Aloe vera and Thuja orientalis leaf extracts, as well as the method to test their antimicrobial and antifungal activity.

Resveratrol can be recognized as a best nutraceutical. Resveratrol is a novel nutraceutical in which not many details are known therefore an attempt was made to review the details which may be used for the further research. Resveratrol is known to be a polyphenol named as stilbenoid group which is a phytoalexin secreted by more than 70 plant species which is having many pharmacological activities like anticancer, anti-inflammatory, anti-ageing, neuroprotective, cardioprotective, anti-microbial and etc. This natural table top food has a lower bioavailability with lower aqueous solubility. From this review we can conclude that resveratrol is a unique complex having various properties with lots of other benefits.

The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based microparticles (SLMs) has advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid microparticles.