Formulation and Characterization of Solid Lipid Microparticles

Bahurupi, Adnya D.; Burange, Prashant; Tawar, Mukund; Ingole, Shital R.

doi:10.46624/ajphr.2019.v7.i4.002

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipids, such as TPGS, GCC, and PGL, used in NSC are present in semi-solid to liquid form depending on the ambient temperature. Therefore, NSC lipids can be discharged outside the carrier, disrupting the solubilization system for poorly soluble drugs and physically unstable [66,67]. Lipids with high fluidity do not maintain a stable solubilization system.…”

Section: Stability Evaluation Of Nsc Tablets Via Dissolution Ratementioning

confidence: 99%

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

2021

View full text Add to dashboard Cite

This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique. NSC microemulsion formation was confirmed using a ternary phase diagram, while the presence of DUT and lipid entrapment in NSC was confirmed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction revealed the amorphous properties of NSC. The prepared all NSC had excellent flowability and enhanced DUT solubility but showed no significant difference in drug content homogeneity. An increase in the lipid content of NSC led to an increase in the DUT solubility. Further the NSC were formulated as tablets using D-α tocopheryl polyethylene glycol 1000 succinate, glyceryl caprylate/caprate, and Neusilin®. The NSC tablets showed a high dissolution rate of 99.6% at 30 min. Furthermore, NSC stored for 4 weeks at 60 °C was stable during dissolution testing. Pharmacokinetic studies performed in beagle dogs revealed enhanced DUT bioavailability when administered as NSC tablets. NSC can be used as a platform to develop methods to overcome the technical and commercial limitations of lipid-based preparations of poorly soluble drugs.

show abstract

Section: Stability Evaluation Of Nsc Tablets Via Dissolution Ratementioning

confidence: 99%