Pyrimido pyrimidine and its derivatives are interesting class of nitrogen containing heterocyclic compounds which are widely found in bio-organic and medicinal chemistry with application in drug discovery. Pyrimido [4,5-d] ABSTRACTGuanidine hydrochloride (1) on treatment with bis(methylthio)methylene malononitrile (2) in N,N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate gives diimino pyrimido pyrimidine (3). The later were further reacted with various substituted 2-amino benzothiazoles (4) to gives bis (diimino benzothiazolo pyrimido pyrimidines) (5a-g). All these synthesized compounds were screened for their antimicrobial activity.

No abstract