A generalized concept of philicity is introduced through a resolution of identity, encompassing electrophilic,
nucleophilic, and radial reactions. Locally, a particular molecular site may be more prone to electrophilic
attack or another may be more prone to nucleophilic attack, but the overall philicity of the whole molecule
remains conserved. Local philicity is by far the most powerful concept of reactivity and selectivity when
compared to the global electrophilicity index, Fukui function, local softness, or global softness because it
contains information about almost all of the known global and local descriptors of chemical reactivity and
selectivity.
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