Endoglucanase (EG) is a key enzyme during enzymatic preparation of cellulose nanocrystals (CNCs). Myceliophthora thermophila is a thermophilic fungus that has thermal properties and a high secretion of endoglucanases (EGs), and could serve as potential sources of EGs for the preparation of CNCs. In this work, four different GH families (GH5, GH7, GH12, and GH45) of EGs from M. thermophila were expressed and purified, and their enzymatic characteristics and feasibility of application in CNC preparation were investigated. It was shown that the MtEG5A from M. thermophila has good potential in the enzymatic preparation of CNCs using eucalyptus dissolving pulp as feedstock. It was also observed that there was a synergistic effect between the MtEG5A and other MtEGs in the preparation of CNCs, which improved the yield and properties of CNCs obtained by enzymatic hydrolysis. This study provides a reference for understanding the enzymatic characteristics of different families of EGs from M. thermophile and their potential application in nanocellulose production.

Heel fissures are splits or cracks in the epidermis, which can manifest as a consequence of anhidrosis and may or may not present with hyperkeratosis. Epidermal fissures are superficial and not considered to be a wound at this early stage. However, with increased pressure these splits become deeper, involving the dermis so that they begin to bleed and result in pain on weight-bearing activities. These fissures are regarded as partial-thickness skin wounds and are at increased risk of developing infection. In Theory anyone can get a cracked heel or fissure soles but certain conditions predisposing to fissure soles are  Congenital causes - Juvenile Plantar Dermatosis Acquired causes - Eczema, Atopic Dermatitis, Tinea pedis,Psoriasis especially Palmoplantar psoriasis, Palmoplantar Keratodermas, Leprosy, Systemic causes-Diabetes mellitus, Hypothyroidism, Scleroderma, Rheumatoid arthritis.

Acne vulgaris is multifactorial in origin where Propionibacterium acnes and altered keratinisation are some of the factors which contribute to the inflammation and obstruction of the pilosebaceous unit. Acne causes the formation of pleomorphic lesions like comedones, papules, pustules, nodules and cysts which may lead to scarring. Lesions of acne are predominantly seen on the face, chest, back, shoulders and upper arms. The aim of the study is to understand the psychological impact that acne vulgaris has on patients in a tertiary care hospital. The study will be carried out over a period of two years from May 21 to May 23 in Terna Speciality Hospital and Research Centre in Nerul, Navi Mumbai, in the Department of Dermatology, Venereology and Leprosy in collaboration with the Department of Psychiatry in Terna Speciality Hospital and Research Centre in Nerul, Navi Mumbai. This study is done to get a deeper look at the psyche of the people suffering from it and what can be done to manage it better.