No abstract

Continuous monitoring of drug concentrations in blood plasma can be beneficial to guide individualized drug administration. High interpatient variability in required dosage and a small therapeutic window of certain drugs, such as anesthetic medications, can cause risks and challenges in accurate dosing during administration. In this work, we present a sensing platform concept using a smart hydrogel micro resonator sheet with medical ultrasound readout that is integrated on the top of a catheter. This concept is validated invitro using glucose as an easy to access and handle target analyte. In the case of continuous glucose measurement, our novel catheter-mounted sensing platform allows the detection of glucose concentrations in the range of 0 mM to 12 mM. While these experiments use a well-known glucose-sensitive smart hydrogel for proof-of-principle experiments, this new sensing platform is intended to provide the basis for continuous monitoring of various intravenously applied medications. Selectivity to different drugs, e.g., fentanyl, can be accomplished by developing a corresponding smart hydrogel composition. Clinical Relevance-Many intravenous medications, especially anesthetics, show considerable pharmacokinetic intersubject variability. Continuous monitoring of intravenous analyte concentrations would enable individualizing the administration of these drugs to the specific patient.

No abstract

No abstract

Early diagnosis of the disease can appreciably improve the survival rate or facilitate effective treatment with different modalities. In the field of disease diagnosis; nanomaterial-based biosensing and bioimaging techniques are lifting hopes for point-of-care cancer diagnosis with ultra-high selectivity and sensitivity. Graphene, including twodimensional (2D) graphene films, three-dimensional (3D) graphene architectures, Graphene dots, and graphene hybrids (GHs) nanostructures have attracted the researcher`s interest in the field of biosensing and bioimaging owing to their properties. Versatile platforms of graphene nanomaterials make it as germane to detect the biomarkers at the early stage of cancer. This review selectively summarizes the recent progress in using graphene-based nanomaterials for detecting lung cancer biomarkers. Explicitly, graphene-electrochemical biosensors, which are classified according to sensing mechanisms and targets (CEA, NSE, hTERT, CYFRA21-1), are thoroughly discussed. Herewith, future scopes and challenges with other matrices, nano-scaffolds have also discoursed in the conclusion and future perspective. GUB JOURNAL OF SCIENCE AND ENGINEERING, Vol 5(1), Dec 2018 P 51-59