Aim: The aim of this study is to predict the response of neoadjuvant chemotherapy (NACT) based on preoperative molecular subtyping of locally advanced breast cancer patients. Materials and Methods: The present single-blind, observational study was conducted at the tertiary health-care center of Acharya Vinoba Bhave Rural Hospital from October 2018 to September 2020. This study comprised 46 patients suffering from breast cancer with TNM stage IIIA and IIIB. The patients received either NACT with cyclophosphamide/adriamycin/5-fluorouracil or paclitaxel, respectively, followed by the standard surgical procedure of modified radical mastectomy. Baseline ultrasound was followed by Trucut biopsy of the tumor which was done with 18-G Bard Trucut biopsy needle under local anesthesia in all aseptic conditions. The specimens were collected and preserved in formalin and were sent for the assessment of tumor histological examination, Scarff-Bloom-Richardson grade, and immunohistochemistry (IHC) evaluation. Depending on the luminal status obtained by IHC preoperatively, further response to chemotherapy was assessed. Results: In the CAF group, patients with human epidermal growth factor receptor 2/neu (HER2/neu)-enriched status had (91.40% ± 7.76%) tumor response followed by luminal B status (89.33% ± 5.77%), triple-negative status (87.34% ± 9.55%), and finally luminal A status with (84.87% ± 8.11%) a statistically nonsignificant relation. In the paclitaxel group, patients with triple-negative status had a tumor response of (96.59% ± 4.48%) followed by luminal B status (96.28% ± 3.27%), HER2/neu-enriched status (91.33% ± 6.85%), and finally luminal A status (82.40% ± 11.29%) with a statistically significant relation (P = 0.023). Conclusion: It can be concluded from the results that overall, HER2/neu-enriched and triple-negative status patients showed better tumor response to NACT in both groups.

Introduction and Objective: Worldwide, breast carcinoma is among the most common carcinoma in females. It is commonly seen site-specific carcinoma in females. Due to lack of education, breast carcinoma patients present in later stages of the disease to healthcare facilities, especially in developing nations. Patients with Locally advanced carcinoma breast (LABC) are commonly seen in developing nations and its treatment multidisciplinary approach. This study is our experience of clinical profile and LABC in a rural setup. Methodology: This is a retrospective and prospective study done in the medical college. Data was taken from 72 cases that were operated on at the institute from July 2018 to June 2021 and diagnosed with LABC. Patients who had histological evidence of malignancy were undergone surgery and other treatment modalities like neoadjuvant chemotherapy, adjuvant chemoradiation, and hormonal therapy. Results: Seventy-two patients diagnosed with LABC over three years were included in the study. The mean age was 51 years. The tumor size was more than 5cm in 60 (83.3%) patients. Involvement of axilla was present in 62 (86.1%) patients. All patients were diagnosed with histopathology after core needle biopsy. Neoadjuvant chemotherapy was given to 62 (86.1%) patients. Most of the patients (65) were undergone MRM as surgery, while the remainder (7) were undergone breast conservation therapy. Very few patients had postoperative complications, but with limited follow-up until this study, 5 (6.9%) patients had a recurrence of their study. Conclusion: In developing nations high percentage of Locally advanced breast carcinoma at presentation result in poor prognosis, high rate of metastasis, and mortality. Awareness and education about breast health and multimodality treatment of LABC will have long-term effects to decrease morbidity and mortality and improve outcomes.

Cholelithiasis is very common problem affecting humans. Laparoscopic cholecystectomy (LC) has become gold standard for the management of symptomatic cholelithiasis [2]. Approximately 2% to 14% of patients may require conversion to open surgery for various factors and complications [2,4]. It would be very useful if there is established criteria to know the chances or risk of conversion to open surgery preoperatively. This study is to predict difficult laparoscopic cholecystectomy by clinical, pathological, and radiological assessment. Methodology: In this multi-center prospective study all patients require surgery in the form of cholecystectomy for reasons like acute and chronic cholecystitis. Sixty patients who underwent laparoscopic cholecystectomy between July 2020 and June 2021 met the inclusion criteria. Findings during surgery were divided into categories like easy, difficult, and very difficult laparoscopic cholecystectomy based on operative parameters like total time for surgery, injury to cystic duct or artery, spillage of stones of gallbladder, frozen Callot’s Triangle, and convert to open surgery. Results: Patients included in the study were divided into three groups, easy, difficult, and very difficult, in each parameter taken into account for surgery. All patients of the very difficult group were converted to open surgery eventually. Mean conversion rate in our study was 6.7%.

Renal stone is a common condition affecting human beings of both genders and all age groups worldwide. Their presentation vary from unilateral loin region pain to nausea vomiting, to burning micturation or even haematuria. Patient profile of renal stone disease differs from one geographical region to another. Therefore this prospective observational study was conducted inDattaMeghe medical college, Wanadongri, Nagpur to find out patient characteristics of this region. 100 patients were included in the study. 82% patients were females most of whom were housewives. 48% patients belonged to the age group 41-60 years. Most common presentation was left sided flank pain. CT scan and USG abdomen were equally accurate in determining the size of the renal stone. Most of the females were managed conservatively whereas most males required intervention like URS or PCNL for their treatment.