This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of Caesalpinia sappan L. a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in heartwood of Caesalpinia sappan L.induced cell death in breast cancer (MCF-7) cells. The therapeutic property was further proved by docking the Brazilin A molecule against BCL-2 protein (an apoptotic inhibitor) using auto dock tools.

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Introduction: Sida acuta is known as common wireweed, and has a pantropical distribution. Antioxidants fight against free radicals and prevent a variety of diseases. Anti Inflammatory reaction is the ability of a substance to reduce swelling or inflammation. Antidiabetic substances are defined as agents which help in maintaining the level of glucose in the blood. Aim: Present study was aimed at assessing the in vitro antidiabetic and antiinflammatory potentials of Sida acuta leaf ethanolic extract.  Methods: Sida acuta was purchased and its ethanolic extract was prepared. Protein denaturation inhibition, DPPH radical scavenging, alpha amylase and alpha glucosidase inhibitory assays were carried out in order to check in vitro antiinflammatory, antioxidant and antidiabetic activity spectrophotometrically..  The data were analysed using one-way analysis of variance  (ONE-WAY ANOVA) to see the statistical significant among the different concentrations of extract. P<0.05 levels were considered as statistical significance. Results: The extract of Sida acuta was compared with aspirin and an antiinflammatory reaction was analysed. Statistically significant at the levels of p < 0.05.The extract proved to contain antiinflammatory and antioxidant reactions. Alpha amylase and alpha glucosidase activity was analysed by comparing the extract with metformin. Conclusion: Sida acuta can be used for the management and treatment of various diseases and disorders. It can be used for the treatment of diabetes and cancer.

Ficus species, auspicious in many cultures worldwide are sources of novel bioactive secondary metabolites. The mechanism by which they exhibit antioxidant and apoptotic properties is scant. The main objective of the current study was to evaluate the properties of activity guided fractionated bark methanol extract of Ficus religiosa. As the methanol extract exhibited highest antioxidant activity it was evaluated for secondary metabolites and therapeutic properties. UPLC-MS analysis of the extract identified the 11 and five secondary metabolites including the rutin, 3-caffeoylquinic acid, luteolin 7-O-rutinoside, 6-C-glucosyl-8-C-arabinosylapigenin and kaempferol-3-O-rutinoside were reported. The MTT assay results identified minimal cytotoxicity for non-cancerous cell line (HEK 293 T) and maximum cell death for human breast cancer cells, MDA-MB-231 (EC50, 91.32 ± 4.21µ g.mL− 1). A high degree of DNA fragmentation in MDA-MB-231 cells subjected to the extract was observed. A clear indication of apoptosis via chromatin condensation was visualized by CLSM. The apoptotic response to treatment was also apparent in the increase in BAX along with the proteolytic cleavage of PARP-1 and a decreased Bcl-2 levels as revealed by Western blot analysis. The MDA-MB-231 cells upon exposure to the extract (91µ g.mL− 1), stimulated cells to early apoptosis (32.5%) and apoptosis (61.6%) as evidenced by flow cytometer studies. Apoptotic cells being represented by a sub G0/G1 population (86.25%) seen to the left of the G0/G1 peak were recorded. The presence of novel bioactive compounds has uncovered possible therapeutic values by modulating antioxidant and apoptosis leading to the development of potential alternative anticancer drugs.