Background:Increased oxidative stress has emerged as one of the prime factors in the pathogenesis of periodontitis. Hence, antioxidant therapy may become a promising tool in the treatment of periodontal disease. Uric acid (UA) being a major antioxidant in saliva can be used as a marker to assess the total antioxidant capacity.Aim:The aim of the study was to investigate the influence of orally administered antioxidants (lycopene and green tea extract) on periodontal health and salivary UA levels in gingivitis patients as an adjunct to scaling and root planing (SRP).Materials and Methods:Thirty systemically healthy participants having generalized gingivitis were randomly distributed into two groups. Control group participants received full mouth oral prophylaxis, while test group participants received oral lycopene and green tea extract (CLIK®) for 45 days along with complete oral prophylaxis. Plaque index (PI), sulcular bleeding index (SBI), and salivary UA levels were evaluated at baseline and 45 days after SRP. Data were analyzed with t-test, using SPSS software (PASW, Windows version 18.0).Results:Both treatment groups demonstrated statistically highly significant (P ≤ 0.001) reduction in plaque and SBI. After treatment, a highly significant increase (P ≤ 0.001) in the test group and significant (P ≤ 0.05) increase in the control group was observed for salivary UA levels. Posttreatment comparison between test and control group delineated statistically significant results in PI (P ≤ 0.001), SBI (P ≤ 0.001), and salivary UA levels (P ≤ 0.01).Conclusion:Lycopene with green tea extract may prove to be a promising adjunctive prophylactic and therapeutic modality in the treatment of gingivitis patients. However, further studies are needed to evaluate the additive effect of antioxidants with routine oral prophylaxis therapy.

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Introduction The objective of this study was to clinically evaluate an autogenous tooth graft (ATG) as a novel bone graft material in the treatment of Class II furcation defects. ATG is prepared at chairside from a freshly extracted tooth to be used immediately for bone regeneration. It has an advantage over the autogenous and other bone graft materials as it is non‐immunogenic, inexpensive, easily available, and lacks donor‐site morbidity. Case Presentation This study was conducted on three middle‐aged (35 to 55 years) male patients, who had at least one mandibular molar with Class II furcation involvement (a total of 5 sites) and one tooth that required extraction because of poor prognosis and was not endodontically treated. At 9 and 12 months, the mean reductions in horizontal probing depth were (1.40 ± 0.57 mm) and (1.52 ± 0.59 mm), respectively, and the mean gains in linear bone‐fill were (3.90 ± 0.15 mm) and (5.33 ± 0.10 mm), respectively. Conclusions Within the limitation of this study, ATG exhibited ideal properties for alveolar bone regeneration. In addition, this study outlines the chairside method to prepare a graft and highlights the improvement in clinical and radiographic parameters at 9 and 12 months.

Tyrosine kinase inhibitors (TKIs) against targetable mutations such as epidermal growth factor receptor (EGFR) are highly efficient in treating advanced stage lung cancers. The usage of EGFR inhibitors (EGFRI) is associated with an improved response rate and improved Progression-free survival (PFS) compared to chemotherapy. Frequently expressed EGFR mutants include 19del, T790M, L858R and recently discovered secondary mutation C797S. There is also some possibility to improve outcome by focusing on better EGFRI and/or combining EGFRI with other therapies like chemotherapy, vascular endothelial growth factor (VEGF) inhibitors and immunotherapy. This review provides an overview of the current status and potential future for EGFR therapies and LUNG CANCER treatments.

Background: Dentinal hypersensitivity is a one of the leading dental problems and herbal based formulations have been in use recently for the same. Objective: This study was conducted for the evaluation of the safety and efficacy of a novel herbal toothpaste in reduction of dentinal hypersensitivity in vivo. Materials and Methods: A total of12 subjects were randomly taken into consideration as a single group. Brushing instructions were given for 7 days use of toothpaste to all subjects. Sensitivity scores for tactile, air stimulus and cold water were recorded at baseline, 3 rd and 7 th day for the study subjects.Results: There was a significant reduction seen in the clinical parameters evaluated in all subjects at the end of the period of use of the toothpaste compared to baseline. Conclusion:The novel herbal dentifrice can be recommended for treatment of dentinal hypersensitivity.