In multicellular organisms, cell motility is central in all morphogenetic processes, tissue maintenance, wound healing and immune surveillance. Hence, failures in its regulation potentiates numerous diseases. Here, cell migration assays on plastic 2D surfaces were performed using normal (Melan A) and tumoral (B16F10) murine melanocytes in random motility conditions. The trajectories of the centroids of the cell perimeters were tracked through time-lapse microscopy. The statistics of these trajectories was analyzed by building velocity and turn angle distributions, as well as velocity autocorrelations and the scaling of mean-squared displacements. We find that these cells exhibit a crossover from a normal to a super-diffusive motion without angular persistence at long time scales. Moreover, these melanocytes move with non-Gaussian velocity distributions. This major finding indicates that amongst those animal cells supposedly migrating through Lévy walks, some of them can instead perform q-Gaussian walks. Furthermore, our results reveal that B16F10 cells infected by mycoplasmas exhibit essentially the same diffusivity than their healthy counterparts. Finally, a q-Gaussian random walk model was proposed to account for these melanocytic migratory traits. Simulations based on this model correctly describe the crossover to super-diffusivity in the cell migration tracks.
Environmental issues are often being discussed in society. The Environmental Education implemented in schools appears to be as an important educational tool, which seeks to raise awareness and stimulate the student to look around and feel an integral part of this environment, also contributing to the improvement of the quality of life, as well as the training of citizens aware. The BIOEDUCA project involved 55 students from the 2nd to 5th year of the Municipal School "Rosina Rodrigues Soares Silva" in the municipality of Barão de Cocais - MG. The environmental theme was approached in a dynamic and interactive way with the children, through lectures, group dynamics and practical activities aiming at the knowledge about the preservation of natural resources, the 3Rs and cycles of the materials. The students demonstrated interest and behavior change during the development of the work. The educational action demonstrated effectiveness in the transference of concepts about the environment and sustainability.
We present an investigation of the mode of road transport in Brazil combining tools of complex networks and real-data. Our analysis involves a data-set based on the service routes inscribed on the Brazilian Transport Agency database. Although connectivity distributions of road networks worldwide are usually claimed as described by a power-law fashion, we report a better fit for the Brazilian case offered by the q-Weibull distribution. In our approach nodes assume the role of localities, whereas links represent service routes among them. Interestingly, a rapid drop takes place on the tail of the data distribution for a particular range of the number of outgoing connections. The mechanism responsible for driving this drop is revealed by investigating the spectral centrality of the network and different patterns of disassortative mixture, for both incoming and outgoing distributions. Besides a discussion about a power law description, we report a contrast with two different distributions. They are interpolated by the q-Weibull one: the Weibull and the q-exponential distributions. Moreover, we study the reciprocity of this network, which reflects the influence of mutual links over dynamical processes. This kind of analysis is indispensable for studies on human mobility, shipping, and a multi-modal perspective.
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