Duchenne muscular dystrophy (DMD) is a genetic disease, which is associated to progressive skeletal muscle degeneration. In humans, DMD has early onset, causes developmental delays, and is a devastating disease that drastically diminishes the quality of life of the young individuals affected. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of Duchenne muscular dystrophy. Male mdx and wild type mice within 28 days were used in this study. The animals were trained in a stepped swimming protocol for four consecutive weeks. It was veri ed that swimming was able to reduce signi cantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius and hippocampus and striatum in exercised animals. Swimming has also prevented lipid peroxidation in diaphragm. Besides, this swimming protocol was able to increase free thiols in gastrocnemius, diaphragm and in all central nervous system structures. These results showed that a protocol of swimming as an aerobic exercise of low intensity, for four weeks, prevented aversive memory and habituation in mdx mice.
Objetivo: Verificar as regiões de maior aumento de temperatura nos nadadores e a correlação das imagens com as queixas álgicas. Métodos: Trata-se de um estudo clínico observacional, transversal do tipo censo, composta por 12 atletas de natação do complexo aquático/ANADO. Os instrumentos da coleta de dados foram: ficha de avaliação, mapa de desconforto, escala analóga visual (EVA) e para as imagens, utilizada a câmera termográfica. As coletas foram realizadas individualmente com seus devidos trajes de banho em uma sala previamente organizada. Resultados: A amostra foi composta por 6 nadadores do sexo masculino com média de idade de19,8 ± 2,6 e 6 do sexo feminino com média 18,0 ± 4,2. Quanto às queixas álgicas, 7 atletas referiam dor em diferentes locais, sendo o ombro (p=0,048) e braço (p=0,049) os locais mais incidentes e intensidade moderada, a maior queixa. Em relação à temperatura, os homens apresentaram maior temperatura, quando comparados ao sexo feminino nos seguintes segmentos corporais: ombro direito anterior (p=0,001); Ombro esquerdo anterior (p=0,002); ombro esquerdo posterior (p=0,005); braço direito anterior (p=0,001); braço esquerdo anterior (p=0,002); braço direito posterior (0,015); braço esquerdo posterior (0,009) e coxa anterior e posterior direita (p=0,006) e (p=0,005). Houve diferença significativa quando comparada a dor entre os sexos, e as mulheres apresentaram mais queixas álgicas (p=0,049) e aqueles atletas que treinam há menos tempo, referiram mais dor (p=0,040), mostrando assim que não houve correlação entre dor e temperatura. Conclusão: Conclui-se que as regiões de maior aumento de temperatura em ambos os sexos foram ombro esquerdo posterior e braço esquerdo posterior, não havendo a correlação das queixas álgicas com a da temperatura corporal. Palavras-chave: termografia; natação; lesão.
Duchenne muscular dystrophy (DMD) is a genetic disease, which is associated to progressive skeletal muscle degeneration. In humans, DMD has early onset, causes developmental delays, and is a devastating disease that drastically diminishes the quality of life of the young individuals affected. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of Duchenne muscular dystrophy. Male mdx and wild type mice within 28 days were used in this study. The animals were trained in a stepped swimming protocol for four consecutive weeks. It was verified that swimming was able to reduce significantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius and hippocampus and striatum in exercised animals. Swimming has also prevented lipid peroxidation in diaphragm. Besides, this swimming protocol was able to increase free thiols in gastrocnemius, diaphragm and in all central nervous system structures. These results showed that a protocol of swimming as an aerobic exercise of low intensity, for four weeks, prevented aversive memory and habituation in mdx mice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.