Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.

Carbazoles, in view of incorporating an indole nucleus in their structure and their close structural resemblance to phenothiazine, have been attracting increasing attention as pharmacodynamic agents.1"5The present communication describes the synthesis and biological evaluation of iV-alkylaminocarbazoles, tetrahydrocarbazoles, and those in which one of the phenyl rings has been enlarged to a seven-membered ring system. Chemistry. The desired intermediate biphenyls were readily obtained by condensing the appropriate 2-bromonitrobenzene with the corresponding iodobenzene under Ullmann's conditions6 and the products were purified by silica gel column chromatography.

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