Background: The resistance of the bacteria toward the antibiotics is growing day by day, and it is a serious threat globally. The reasons are self-medication, unjustified prescription of antibiotics, high use of antibiotics in livestock, and nonadherence to antibiotic treatment guidelines by prescribers. The aim of the present study is to assess the knowledge and attitude of the prescribers toward the prescription of antibiotics and antibiotic resistance. Methodology: A descriptive cross-sectional study was conducted using a questionnaire which contains questions to assess the knowledge and attitude of the prescribers. The questionnaire had three parts: the first part was used to obtain the basic demographic characteristics from participants, the second part had questions regarding the antibiotic indication in common infections, and the third part assessed the knowledge questions about antibiotic resistance. The questionnaire was attempted by eighty prescribers. Results: More than 50% of the medical practitioners agreed that antibiotics had to be used for some common infections such as acute gastroenteritis, asymptomatic bacteriuria in nonpregnant patients, and burn wounds with no evidence of infection. The knowledge of the prescribers regarding antibiotic resistance is variable. Conclusion: A higher percentage of the prescribers responded in favor of the use of antibiotics for common infections. It requires an awareness program to sensitize the prescribers regarding the prescription of antibiotics for appropriate indications and the seriousness of antibiotic resistance.

Objective: The present study aims to evaluate the awareness of a sample of the general population and health-care professionals regarding the use of antibiotics and antibiotic resistance and identify the factors associated with antibiotic resistance. Methods: This prospective questionnaire-based study was conducted for 3 months, from July to September 2020, in Karaikal, Puducherry (India). The health professionals included doctors in pre- and paraclinical teaching departments (those not involved in clinical practice), laboratory technicians, and PhD students pharmacists. The questionnaire had two parts which health professionals answered, whereas the general population answered only the second part. Findings: About 38.5% of the population reported using antibiotics frequently among the responses obtained. Around 66.5% of the general population usually stop the antibiotic within 1 or 2 days after they feel better, and 11% of the people believed that adding an extra antibiotic would make them better. Among the health professionals, more than 90% responded that self-medication is the major reason for antibiotic resistance and was unsure of the overprescription of antibiotics. Conclusion: The results show variable responses and suggest the need for intervention programs to increase the knowledge among the general population regarding the rational use of antibiotics.